Autologous Blood Concentrates

Autologous Blood Concentrates
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Описание книги

Since its discovery over two decades ago, platelet-rich plasma (PRP) and its derivatives have become a mainstay in oral and maxillofacial surgery and, more recently, in other dental specialties as well. As technology continues to allow significant innovation in this field, more and more formulations and products are being discovered and marketed to dentists. In the second edition of this bestselling book, Dr Garg sheds the salesmanship that often swirls around PRP and instead focuses on the science, biology, and clinical applications of this natural biomaterial. Credited as a co-discoverer of PRP, he knows how to break down the science and explain how autologous blood concentrates work to speed healing and promote tissue regeneration. This natural, inexpensive, and safe material has enormous potential in a dental clinic, and Dr Garg wants to make sure every clinician has access to information that is easy to digest and easy to apply. This book is thereby a roadmap to incorporating autologous blood concentrates into clinical practice. The early chapters focus on the biology of what goes on when blood is collected and centrifuged and reintroduced into wound sites as well as how to prepare the different formulations of autologous blood concentrates. The later chapters demonstrate how to use this material in implant surgery, soft and hard tissue healing, facial cosmetics, and other clinical applications to achieve superb outcomes. With a bonus chapter on phlebotomy, this book is the practical manual novices need and experienced clinicians value.

Оглавление

Arun K Garg. Autologous Blood Concentrates

Contents

Preface

1. Autologous Blood Concentrates: The Science of Natural Wound Healing

Platelet Biology

PRP Growth Factors

PDGF

TGF-β1, TGF-β2, and TGF-β3

FGF

IGF

EGF

VEGF

PRP and Soft Tissue Healing

PRP and Bone Regeneration

What Is PRP?

Ongoing Controversies

Naming and classifying platelet derivatives

Standardizing PRP sequestration and application protocols

Conclusion

2. Medical and Surgical Applications of Autologous Blood Concentrates

Cardiothoracic Surgery

Sports Medicine

Osteoarthritis

Tendinopathy

Dentistry

Ophthalmology

Podiatry

Veterinary Medicine

Neurosurgery

Other Clinical Applications

Spinal applications

Chronic wound healing

General surgery

Conclusion

References

3. Biologic Growth Factors, PRP, and Bone Morphogens in Bone Regeneration Procedures

Platelet-Derived Growth Factor

Insulinlike Growth Factor

Fibroblast Growth Factors

Transforming Growth Factor β

Platelet-Rich Plasma

Bone Morphogenetic Proteins

rhBMP-2

Gene Therapy

Mesenchymal Stem Cells

Exosomes

References

4. Eight Forms of Autologous Blood Concentrate: Preparation and Clinical Applications

Biology of Blood

PRP Liquid

Implantology

Dermal microneedling

Hair regrowth

PRP Gel

Crestal sinus elevation

Third molar socket grafting

PRP Membrane

Socket grafting

Alveolar ridge splitting/expansion

Perforated sinus membrane repair

Gingival recession defect grafting

PRP Exudate

PRP Plug

Extraction socket defects

PRP Sticky Bone

Horizontal ridge augmentation

PRP with Heated Proteins

PRP–Heated Protein Biomembrane

Conclusion

5. Dental Implants, Osseointegration, and Autologous Blood Concentrates

Dental Implants and Osseointegration

The mechanism of osseointegration

Factors influencing osseointegration

PRP and Dental Implant Osseointegration

Conclusion

6. Oral Cavity Soft Tissue Healing and Autologous Blood Concentrates

Implant Surgery, Soft Tissue Flaps, and PRP

Gingival Recession and PRP

Free gingival grafts

Connective tissue grafts

Excessive Root Exposure: Repositioned Flaps, Allogeneic Dermis, and PRP

PRP and Other Forms of Oral Soft Tissue Wound Healing

PRP’s Antimicrobial Properties and Oral Soft Tissue Wound Healing

Conclusion

References

7. Oral Cavity Hard Tissue Healing and Autologous Blood Concentrates

Periodontal Disease and Periodontal Defects

Alveolar Ridge Preservation

Ridge Augmentation Grafting

Third Molars

Sinus Elevation Grafting

Conclusion

References

8. Facial Cosmetics and Autologous Blood Concentrates

Traditional Cosmetic Surgery

Rhytidectomy

Blepharoplasty

Upper eyelid

Lower eyelid

Autologous fat transfer. Nonparticulated dermal graft

Facial lipofilling

Facial Rejuvenation Procedures

Microneedling

Facial rejuvenation

Acne

Hair loss

Dermal fillers

Conclusion

References

9. The Future of Autologous Blood Concentrates

3D Printing

Laser Therapy

Peripheral Nerve Regeneration

Ultrasound Technology

Rethinking the Status Quo

Conclusion

References

10. Principles and Practice of Phlebotomy

Venipuncture Equipment

Blood collection

Evacuated tube system

Winged blood collection set

Needles

Needle disposal

Collection tubes

Blood collection rack

Tourniquet

Gloves, gauze pads, and bandages

Organizing and transporting equipment

Venipuncture Procedure

1. Positioning the patient

2. Sanitizing your hands and applying gloves

3. Locating and identifying veins

Median cubital vein

Cephalic vein

Basilic vein

4. Performing palpation

5. Cleaning the puncture site

6. Applying the tourniquet

7. Performing the venipuncture

Stabilizing the vein

Inspecting the needle

Inserting the needle

Technique for back of hand venipuncture

8. Filling the tubes

9. Removing the needle

10. Disposing of the needle

Technical Complications. Lack of blood flow. Needle position

Collapsed vein

Bad evacuated tube

Nerve injury

Types of nerve damage injuries

Arterial puncture

Hematoma formation

Patient-Related Complications. Anxious or nervous patients

Needle phobia

Syncope

References

Index

Отрывок из книги

Autologous Blood Concentrates, Second Edition

1 Autologous Blood Concentrates: The Science of Natural Wound Healing

.....

52. Hartley PS. Platelet senescence and death. Clin Lab 2007;53:157–166.

53. White JG. Electron microscopy methods for studying platelet structure and function. Methods Mol Biol 2004;272:47–63.

.....

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