An Essay on the Effects of Opium. Considered as a Poison

An Essay on the Effects of Opium. Considered as a Poison
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Awsiter John. An Essay on the Effects of Opium. Considered as a Poison

TO THE. President and Fellows. OF THE. Royal College of Physicians

PREFATORY DISCOURSE

THE. EFFECTS. OF. OPIUM,

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Among People who are unacquainted with the Nature of Opium, it is a received Opinion, – That as it will, when taken in proper Doses, lull Pain, and procure Rest; so, in large Quantities, that it will terminate a Life of Cares, by an easy and quiet Death; but it is not so: this argument is directly contrary to the Nature of our Existence, the animal Oeconomy being so formed, as not to bear a total Solution, without some Agonies. Thus, when this Drug is received into the Stomach, in Quality of a Poison, easy Rest is denied, the Senses, roused by their threatened Solution, force the animal Powers into immediate Conflict with the noxious Body, which produces Convulsions, and other dreadful Symptoms, the Forerunners of Death. – The Drug is besides of so strong a Nature, that, though taken only into the Stomach, it can change the Colour of the Skin, and even of the Linen wore next it; a Body also, many Hours after Death, will smell so strongly of it, as to determine whether it was the Instrument of Destruction used.

I might have encreased the Bulk of this Essay, by expatiating on the Effects of Opium upon the arterial Fluid; I could inform you, that the Power of it is diffused by the Stimulus of the recurrent Nerves, to their Origin in the Cerebellum, whence, by Consent of Parts, the whole System partakes of the Affect, and the contaminated Fluid is propelled by them, through the Heart into the Arteries, and communicated to the most distant Parts of the Body; also that the Skin is formed by very minute Fibres of the Nerves, interwoven with arterial Fibres and Veins, forming numerous Compages of secerning Vessels, &c. &c. but these are Subjects best suiting the medicinal Powers of Opium, which being derogatory from my Design, are purposely avoided, and, but that these Pages are for the Perusal of more than the Circle of Physical Gentlemen, the Cases alone would have been inserted, without even giving the natural History of the Drug; for this same Reason, the Prescriptions are set down in English, and the whole Essay disrobed of technical Expressions, as far as the Subject will allow.

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Though it is a received Opinion, that Opium, with us, and other Countries where not manufactured, has not near the Strength of that used by the People where it grows; yet in Turkey they can venture to take it in larger Quantities; and hence it is manifest, that the Effects would be more pernicious amongst them, if they did not use it in a most pure State; and though Habit might conduce to the Constitution bearing it in much larger Doses, than we in England dare give it, yet certainly the constant Use of it, unless when of a most fine Texture of Parts, must sooner prove hurtful, than the immoderate and constant Drinking of Wines, and Spirits; and by this Means, the Lives of the major Part of the Eastern Countries, where it is so much requested, would drop in the Flower of their Youth, and whole Nations, in the Space of a Century, be depopulated.

The ancient Accounts of the Manner of gathering Opium, was, according to Diascorides, by the milky Juice being collected from Time to Time, that distilled from the wounded Head of the Poppy; thus gathered, it is entirely pure, and being taken, gives no disagreeable Sensation to the Stomach. This Extract being almost wholly volatile, immediately enters into Action, and discharges itself by Perspiration, opening the Pores, and refreshing the Spirits, without any attendant Injury; and daily Experience will convince every one who will put it to the Tryal, that the purer the Opium, in the greater Quantity it may be taken, unattended with the Nausea, Vertigo, and Tremor, which are so often the Consequences of it with us, though used in small Doses. Tournefort, Page 292, Materiæ Medicæ, informs us, that Opium, or Laudanum, does not only pass off freely by Perspiration, but cures those Distempers arising from Obstructions of the Organs of Respiration in hot Countries, without any Inconvenience whatever, which cannot be said of it, in such Cases, in England, though assisted with volatile and cordial Medicines. This seems a palpable Contradiction to the Opinion of Doctor Jones, who says, that Opium may be taken in much larger Doses, in Cold, than in hot Climates.

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