Haematology

Haematology
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Описание книги

Haematology Diagnostic haematology requires the assessment of clinical and laboratory data together with a careful morphological assessment of cells in blood, bone marrow and tissue ­fluids. Subsequent investigations including flow cytometry, immunohistochemistry, cytogenetics and molecular studies are guided by the original morphological findings. These targeted investigations help generate a prompt unifying diagnosis. Haematology: From the Image to the Diagnosis presents a series of cases illustrating how skills in morphology can guide the investigative process. In this book, the authors capture a series of images to illustrate key features to recognize when undertaking a morphological review and show how they can be integrated with supplementary information to reach a final diagnosis. Using a novel format of visual case studies, this text mimics ‘real life’ for the practising diagnostic haematologist – using brief clinical details and initial microscopic morphological triage to formulate a differential diagnosis and a plan for efficient and economical confirmatory investigation to deduce the correct final diagnosis. The carefully selected, high-quality photomicrographs and the clear, succinct descriptions of key features, investigations and results will help haematologists, clinical scientists, haematology trainees and haematopathologists to make accurate diagnoses in their day-to-day work. Covering a wide range of topics, and including paediatric as well as adult cases, Haematology: From the Image to the Diagnosis is a succinct visual guide which will be welcomed by consultants, trainees and scientists alike.

Оглавление

Barbara J. Bain. Haematology

Table of Contents

Guide

Pages

Haematology. From the Image to the Diagnosis

Preface

Abbreviations. Full blood count (FBC) components

Others

Normal ranges for commonly used tests (for adults) FBC and differential count

Coagulation tests

Other tests

1 Anaplastic large cell lymphoma with haemophagocytic syndrome

MCQ

2 Bone marrow AL amyloidosis

MCQ

3 Cup‐like blast morphology in acute myeloid leukaemia

MCQ

4 Neutrophil morphology

References

MCQ

5 Primary myelofibrosis

MCQ

6 Sarcoidosis

MCQ

7 Visceral leishmaniasis

MCQ

8 Gelatinous transformation of the bone marrow

MCQ

9 Acanthocytic red cell disorders

MCQ

10 T‐cell large granular lymphocytic leukaemia

MCQ

11 Pure erythroid leukaemia

Reference

MCQ

12 eactive mesothelial cells

MCQ

13 Plasmablastic myeloma

MCQ

14 Septicaemia

MCQ

15 An unstable haemoglobin and a myeloproliferative neoplasm

MCQ

16 Sickle cell anaemia in crisis

Reference

MCQ

17 Acute myeloid leukaemia with t(8;21)(q22;q22.1)

MCQ

18 Chronic neutrophilic leukaemia

References

MCQ

19 Essential thrombocythaemia

References

MCQ

20 Hairy cell leukaemia

MCQ

21 Mantle cell lymphoma in leukaemic phase

Reference

MCQ

22 Infantile osteopetrosis

MCQ

Note

23 Reactive eosinophilia

References

MCQ

24 Stomatocytic red cell disorders

MCQ

25 Reactive lymphocytosis due to viral infection

MCQ

26 Therapy‐related acute myeloid leukaemia with eosinophilia

MCQ

27 Red cell fragmentation syndromes

MCQ

28 NK/T‐cell lymphoma in leukaemic phase

MCQ

29 Myelodysplastic syndrome with del(5q)

MCQ

30 Classical Hodgkin lymphoma

MCQ

31 Cryoglobulinaemia

MCQ

32 Congenital dyserythropoietic anaemia

MCQ

33 Acute monoblastic leukaemia with t(9;11)(p21.3;q23.3)

MCQ

34 Chronic myeloid leukaemia presenting with myeloid sarcoma

Reference

MCQ

35 Glucose‐6‐phosphate dehydrogenase deficiency

Reference

MCQ

36 Leukaemic presentation of hepatosplenic γδ T‐cell lymphoma

MCQ

37 Myelodysplastic syndromes

MCQ

38 Pelger–Huët anomaly

Reference

MCQ

39 Russell bodies in lymphoplasmacytic lymphoma

MCQ

40 T‐cell prolymphocytic leukaemia

MCQ

41 Myeloid maturation arrest

References

MCQ

42 MDS/MPN with ring sideroblasts and thrombocytosis

Reference

MCQ

43 Acute myeloid leukaemia with inv(16)(p13.1q22)

MCQ

44 Babesiosis

References

MCQ

45 Haemoglobin E disorders

MCQ

46 Juvenile myelomonocytic leukaemia

Reference

MCQ

47 Non‐haemopoietic tumours

MCQ

48 Richter transformation of chronic lymphocytic leukaemia

MCQ

49 Sickle cell–haemoglobin C disease

Reference

MCQ

50 T cell/histiocyte‐rich B‐cell lymphoma

MCQ

51 Miliary tuberculosis

Reference

MCQ

52 Pure red cell aplasia

MCQ

53 Lymphoblastic transformation of follicular lymphoma

MCQ

54 Primary hyperparathyroidism

MCQ

55 Gamma heavy chain disease

Reference

MCQ

56 Acute promyelocytic leukaemia with t(15;17)(q24.1;q21.2)

MCQ

57 AA amyloidosis

Reference

MCQ

58 Acquired sideroblastic anaemia

MCQ

59 Diffuse large B‐cell lymphoma

MCQ

60 Hickman line infection

Reference

MCQ

61 Monocytes and their precursors

MCQ

62 Paroxysmal cold haemoglobinuria

MCQ

63 Transient abnormal myelopoiesis

MCQ

64 Systemic lupus erythematosus

MCQ

65 Granular blast cells in acute lymphoblastic leukaemia

References

MCQ

66 Chronic myelomonocytic leukaemia

Reference

MCQ

67 Burkitt lymphoma/leukaemia

MCQ

68 Gaucher disease

MCQ

69 Myelodysplastic syndrome with haemophagocytosis

MCQ

70 Primary oxalosis

MCQ

71 Acute myeloid leukaemia with inv(3)(q21.3q26.2)

MCQ

72 Autoimmune haemolytic anaemia

Reference

MCQ

73 Chronic eosinophilic leukaemia with FIP1L1‐PDGFRA fusion

MCQ

74 Leukaemic phase of follicular lymphoma

References

MCQ

75 Megaloblastic anaemia

MCQ

76 Reactive bone marrow and an abnormal PET scan

MCQ

77 Acute megakaryoblastic leukaemia

MCQ

78 Erythrophagocytosis and haemophagocytosis

References

MCQ

79 Hyposplenism

References

MCQ

80 Acquired haemoglobin H disease

MCQ

81 Cystinosis

MCQ

82 Familial platelet disorder with a predisposition to AML

Reference

MCQ

83 Nodular lymphocyte predominant Hodgkin lymphoma

MCQ

84 Acute monocytic leukaemia with NPM1 mutation

References

MCQ

85 Adult T‐cell leukaemia/lymphoma

MCQ

86 Hereditary elliptocytosis and pyropoikilocytosis

MCQ

87 Sézary syndrome

MCQ

88 Spherocytic red cell disorders

MCQ

89 Acute myeloid leukaemia and metastatic carcinoma

MCQ

90 Chédiak–Higashi syndrome

Reference

MCQ

91 Cortical T‐lymphoblastic leukaemia/lymphoma

MCQ

92 Trypanosomiasis

MCQ

93 Acute myeloid leukaemia with myelodysplasia‐related changes

MCQ

94 Blastic plasmacytoid dendritic cell neoplasm

Reference

MCQ

95 Inherited macrothrombocytopenias

Reference

MCQ

96 Persistent polyclonal B‐cell lymphocytosis

MCQ

97 Acute myeloid leukaemia with t(6;9)(p23;q34.1)

MCQ

98 B‐cell prolymphocytic leukaemia

MCQ

99 Various red cell enzyme disorders

Reference

MCQ

100 Sea‐blue histiocytosis in multiple myeloma

References

MCQ

101 Enteropathy‐associated T‐cell lymphoma

MCQ

Further discussion of the themes. 1 Anaplastic large cell lymphoma with haemophagocytic syndrome

2 Bone marrow AL amyloidosis

3 Cup‐like blast morphology in acute myeloid leukaemia

4 Neutrophil morphology

Reference

5 Primary myelofibrosis

Reference

6 Sarcoidosis

Reference

7 Visceral leishmaniasis

References

8 Gelatinous transformation of the bone marrow

Reference

9 Acanthocytic red cell disorders

References

10 T‐cell large granular lymphocytic leukaemia

References

11 Pure erythroid leukaemia

References

12 Reactive mesothelial cells

References

13 Plasmablastic myeloma

References

14 Septicaemia

References

15 An unstable haemoglobin and a myeloproliferative neoplasm

16 Sickle cell anaemia in crisis

17 Acute myeloid leukaemia with t(8;21)(q22;q22.1)

References

18 Chronic neutrophilic leukaemia

References

19 Essential thrombocythaemia

20 Hairy cell leukaemia

21 Mantle cell lymphoma in leukaemic phase

22 Infantile osteopetrosis

References

23 Reactive eosinophilia

Reference

24 Stomatocytic red cell disorders

References

25 Reactive lymphocytosis due to viral infection

References

26 Therapy‐related acute myeloid leukaemia with eosinophilia

Reference

27 Red cell fragmentation syndromes

28 NK/T‐cell lymphoma in leukaemic phase

29 Myelodysplastic syndrome with del(5q)

References

30 Classical Hodgkin lymphoma

31 Cryoglobulinaemia

References

32 Congenital dyserythropoietic anaemia

References

33 Acute monoblastic leukaemia with t(9;11)(p21.3;q23.3)

34 Chronic myeloid leukaemia presenting with myeloid sarcoma

References

35 Glucose‐6‐phosphate dehydrogenase deficiency

References

36 Leukaemic presentation of hepatosplenic γδ T‐cell lymphoma

37 Myelodysplastic syndromes

References

38 Pelger–Huët anomaly

References

39 Russell bodies in lymphoplasmacytic lymphoma

Some Historical Names

References

40 T‐cell prolymphocytic leukaemia

41 Myeloid maturation arrest

42 MDS/MPN with ring sideroblasts and thrombocytosis

References

43 Acute myeloid leukaemia with inv(16)(p13.1q22)

References

44 Babesiosis

References

45 Haemoglobin E disorders

Reference

46 Juvenile myelomonocytic leukaemia

47 Non‐haemopoietic tumours

48 Richter transformation of chronic lymphocytic leukaemia

49 Sickle cell–haemoglobin C disease

Reference

50 T cell/histiocyte‐rich B‐cell lymphoma

51 Miliary tuberculosis

52 Pure red cell aplasia

53 Lymphoblastic transformation of follicular lymphoma

References

54 Primary hyperparathyroidism

55 Gamma heavy chain disease

References

56 Acute promyelocytic leukaemia with t(15;17)(q24.1;q21.2)

57 AA amyloidosis

References

58 Acquired sideroblastic anaemia

References

59 Diffuse large B‐cell lymphoma

60 Hickman line infection

Reference

61 Monocytes and their precursors

62 Paroxysmal cold haemoglobinuria

63 Transient abnormal myelopoiesis

References

64 Systemic lupus erythematosus

References

65 Granular blast cells in acute lymphoblastic leukaemia

66 Chronic myelomonocytic leukaemia

References

67 Burkitt lymphoma/leukaemia

68 Gaucher disease

References

69 Myelodysplastic syndrome with haemophagocytosis

Reference

70 Primary oxalosis

Reference

71 Acute myeloid leukaemia with inv(3)(q21.3q26.2)

72 Autoimmune haemolytic anaemia

References

73 Chronic eosinophilic leukaemia with FIP1L1‐PDGFRA fusion

References

74 Leukaemic phase of follicular lymphoma

Reference

75 Megaloblastic anaemia

76 Reactive bone marrow and an abnormal PET scan

References

77 Acute megakaryoblastic leukaemia

78 Erythrophagocytosis and haemophagocytosis

Reference

79 Hyposplenism

Reference

80 Acquired haemoglobin H disease

Reference

81 Cystinosis

Reference

82 Familial platelet disorder with a predisposition to AML

References

83 Nodular lymphocyte predominant Hodgkin lymphoma

References

84 Acute monocytic leukaemia with NPM1 mutation

85 Adult T‐cell leukaemia/lymphoma

Reference

86 Hereditary elliptocytosis and pyropoikilocytosis

87 Sézary syndrome

Reference

88 Spherocytic red cell disorders

89 Acute myeloid leukaemia and metastatic carcinoma

90 Chédiak–Higashi syndrome

Reference

91 Cortical T‐lymphoblastic leukaemia/lymphoma

References

92 Trypanosomiasis

References

93 Acute myeloid leukaemia with myelodysplasia‐related changes

94 Blastic plasmacytoid dendritic cell neoplasm

Reference

95 Inherited macrothrombocytopenias

References

96 Persistent polyclonal B‐cell lymphocytosis

References

97 Acute myeloid leukaemia with t(6;9)(p23;q34.1)

Reference

98 B‐cell prolymphocytic leukaemia

Reference

99 Various red cell enzyme disorders

References

100 Sea‐blue histiocytosis in multiple myeloma

101 Enteropathy‐associated T‐cell lymphoma

Index

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b

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d

e

f

g

h

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m

n

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p

q

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t

u

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w

x

z

WILEY END USER LICENSE AGREEMENT

Отрывок из книги

Mike Leach MB ChB, FRCP, FRCPath

.....

Professor of Diagnostic Haematology St Mary’s Hospital Campus, Imperial College London and Honorary Consultant Haematologist St Mary’s Hospital, London, UK

There is always more to learn – the study of haematology is a constant journey, not a destination

.....

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