Influence of FOX genes on aging and aging-associated diseases

Оглавление

Elena Tschumak. Influence of FOX genes on aging and aging-associated diseases

FOX GENES AFFECT AGING AND RELATED DISEASES

FOXP2 genes have a direct and indirect effect on aging

Influence of other members of Fox-family on aging processes

FOX genes and anti-aging agents

FOXP2 and neuroplasticity

FOXP2 and neurodegeneration

FOXP2 and Alzheimer

Further aging and neurodegeneration relevant FOXP2 targets

Structure and function of FoxP genes is responsible for his function

Natural products and FOXP Targets

Post-stroke FOXP2 expression and discussion on appropriate animal models to study FOXP2 language function

Further literature:

Отрывок из книги

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ANRIL influences cell cycle as well senescence via upregulation of the tumor suppressor gene p15 (INK4B) (Latrese et al, 2000; Kotake et al., 2011; Peters 2008) and plays a role in breast and another carcinoma, e.g. in gastric, prostate cancer cells and non-small cell lung cancer cell via KLF2 and p21 downregulation (Yap et al., 2010; Nie et al., 2014;1:268–277; Zhang et al., 2014; Hannou et al., 2015; Pasmant et al., 2011) and disturbs miR-99 and miR-449a. LncRNA PINT interacts with PRC2 complex via SUZ12, with plays a role in histone modification and cancer. (Marin-Bejar et al., 2013)

HOTAIR also influences senescence and cancer, e.g., breast tumors as well as endometrial, colorectal, cervical carcinomas and metastasis via H3K27me3 changes and chromatin modifiers, e.g. PRC2. (Kogo et al., 2011; Zhang et al., 2013; Heet al, 2014; Huanget al., 2014; Gupta et al., 2010)

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