Practical Pediatric Gastrointestinal Endoscopy

Practical Pediatric Gastrointestinal Endoscopy
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The  reference text for all those practicing diagnostic and therapeutic pediatric endoscopy – trainees, trainers, specialist endoscopists, gastroenterologists and hepatologists alike.    Practical Pediatric Gastrointestinal Endoscopy , 3rd Edition  provides a comprehensive and up-to-date exploration for the performance of endoscopy in infants, children and young adults. Written in the form of a complete “how to” manual and filled with step-by-step instructions, this book seeks to bring newcomers to the field of pediatric gastrointestinal endoscopy quickly up to speed. The book is also highly useful for experienced specialist endoscopists and gastroenterologists to brush up on best practice in standard techniques and explore advanced topics in the field.  Practical Pediatric Gastrointestinal Endoscopy  highlights the substantial and important differences between performing an endoscopy on a mature adult and performing one in a pediatric patient. The differences discussed include:  GI pathology Subtleties of diagnostic technique specific to children Application of therapeutic endoscopy to specifically pediatric scenarios Anesthesia and sedation Training and skill maintenance Sophisticated endoscopic techniques adapted from adult endoscopy to children and those techniques specifically orientated to problems and diseases mainly encountered in childhood This guide is becoming an essential companion for those of us providing diagnostic and therapeutic endoscopy for children in the world today and opens the door to future possibilities in this ever-evolving field.

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Группа авторов. Practical Pediatric Gastrointestinal Endoscopy

Table of Contents

List of Tables

List of Illustrations

Guide

Pages

Practical Pediatric Gastrointestinal Endoscopy

Personal statements

Contributors

About the Companion Website

1 Introduction

2 History of pediatric gastrointestinal endoscopy

KEY POINTS

The precursors

The fiberscope

Training

Evolution

Conclusion

REFERENCES

3 The endoscopy unit

KEY POINTS

Unit design

Unit management

Equipment

Conclusion

REFERENCES

4 Pediatric procedural sedation and general anesthesia for gastrointestinal endoscopy

KEY POINTS

Introduction

Definitions/spectrum of sedation to general anesthesia

Box 4.1 ASA physical status classification

Assessing risk in the pediatric patient

Predictors of adverse events for GI procedures

Obesity

NPO

Upper respiratory infection

Preparation

Staffing and environment preparation

During sedation and monitoring

End‐tidal capnography

Postsedation care

Conclusion

FURTHER READING

5 Pediatric endoscopy training and ongoing assessment

KEY POINTS

Introduction

Training

Endoscopy skill acquisition

Endoscopy training aids

Training the pediatric endoscopy trainer

Assessment

Assessment based on quality metrics

Direct observational assessment tools

Conclusion

REFERENCES

6 Recertification and revalidation as concepts in pediatric endoscopy

KEY POINTS

REFERENCES

7 The role of the Global Rating Scale in pediatric endoscopy

KEY POINTS

Introduction

Pediatric endoscopy GRS

The future

REFERENCES

FURTHER READING

8 Quality indicators as a critical part of pediatric endoscopy provision

KEY POINTS

Introduction

Conclusion

REFERENCES

9 e‐learning in pediatric endoscopy

KEY POINTS

USEFUL WEBSITES

10 Indications for gastrointestinal endoscopy in childhood

KEY POINTS

Introduction

Diagnostic endoscopy

Therapeutic indications for endoscopy

11 Diagnostic upper gastrointestinal endoscopy

KEY POINTS

Introduction

Indications for EGD

Assembling the equipment and preprocedure check‐up

Endoscope handling

Preparation for esophageal intubation

Techniques of esophageal intubation

Exploration of the esophagus, stomach, and duodenum

Biopsy technique

pH and pH impedance probe placement

Complications

Uncommon, incidental, and rare findings during EGD. Esophageal squamous papilloma (ESP)

Esophageal adenocarcinoma (EAC)

Collagenous gastritis

Late sequelae of severe acid‐induced corrosive gastritis

Pyloric duplication cyst

Heterotopic pancreas

Gastric polyps

Gastric malignancy

Peptic ulcer disease

Intestinal lymphangiectasia

FURTHER READING

12 Pediatric ileocolonoscopy

KEY POINTS

Bowel preparation for colonoscopy

Indications for ileocolonoscopy

Contraindications for ileocolonoscopy

Equipment

Informed consent and preprocedure preparation

Specifics of sedation for colonoscopy

Embryology of the colon relative to ileocolonoscopy

Endoscopic anatomy of the colon and terminal ileum

Torque steering technique – the key to successful ileocolonoscopy

Golden rules of ileocolonoscopy

Technique of ileocolonoscopy. Handling the colonoscope

Getting started and patient positioning

Rectal intubation

Endoscopic clues to a hidden lumen

Exploration of the sigmoid colon and sigmoid–descending junction

Descending colon

Splenic flexure and transverse colon

Hepatic flexure, ascending colon, and cecum

Terminal ileum intubation

Withdrawing

Complications

Common pathology: rectal bleeding. Inflammatory bowel disease

Allergic proctocolitis

Pseudopolyps, juvenile polyps, and polyposis syndromes

Rare pathology. Polyposis syndromes

Peutz–Jeghers syndrome

Familial adenomatous polyposis

Colon cancer

Adenocarcinoma of the colon in ulcerative colitis

Non‐Hodgkin’s lymphoma of the terminal ileum

Isolated Langerhans cell histiocytosis of the colon

Vascular malformation of the colon

FURTHER READING

13 Handling of specimens and orientation of biopsies

KEY POINTS

Introduction

Specimen handling in the endoscopy unit

Specimen handling in the histopathology laboratory

Macroscopic description

Processing, embedding, and microtomy

REFERENCES

14 Enteroscopy

KEY POINTS

Introduction

Double‐balloon enteroscopy technique

Indications for DBE

Pediatric experience

Complications

Training issues and learning curve

Single‐balloon enteroscopy

Spiral enteroscopy

Intraoperative or laparoscopy‐assisted enteroscopy

General complications

Conclusion

FURTHER READING

15 Wireless capsule endoscopy

KEY POINTS

Introduction

Practical approach

Pediatric experience and pathologies. Small bowel IBD and inflammatory pathologies

Polyposis syndromes and other intestinal tumors

Occult or obscure intestinal bleeding

Other indications

Recent developments

Conclusion

REFERENCES

16 Endoscopic ultrasonography

KEY POINTS

Introduction

Instruments and technique

Ultrasound catheter probe (radial EUS)

Front‐loading ultrasound probe

Radial endoscopic ultrasonography

Balloon contact method

Water‐filling method

Balloon contact plus water‐filling method

Linear endoscopic ultrasonography

Appearance of the gastrointestinal wall on EUS images

Indications in children

EUS features in pediatric diseases. Esophageal strictures

Stomach

Pancreatobiliary ducts

REFERENCES

17 Chromoendoscopy

KEY POINTS

Indications. Esophageal disorders

Helicobacter pylori infection and related disorders

Celiac disease

Polyposis syndromes

Inflammatory bowel disease

Other indications

Application technique. Equipment

Methylene blue

Lugol’s solution

Toluidine blue

Indigo carmine

Congo red

Phenol red

Acetic acid

India ink

Patient sedation

Preparation of the mucosa

Staining technique

Recognition of lesions. Barrett’s esophagus and related disorders

Helicobacter pylori infection and related disorders

Celiac disease

Polyposis syndromes

Inflammatory bowel disease

FURTHER READING

18 Confocal laser endomicroscopy in the diagnosis of pediatric gastrointestinal disorders

KEY POINTS

Contrast agents

Upper GI tract

Lower GI tract

Conclusion

FURTHER READING

19 High‐risk pediatric endoscopy

KEY POINTS

Introduction

Patients at high risk for cardiopulmonary and sedation‐related events

Patients at high risk for bleeding

Patients at high risk for perforation

Patients at high risk for endoscopy‐related infections

Exogenous infection transmission

Patient risk factors for endogenous infection transmission

Risk factors for procedure‐related infections

REFERENCES

20 Esophagitis

KEY POINTS

Introduction

Infectious esophagitis

Esophagitis associated with HIV

Esophagitis caused by Candida

Esophagitis caused by CMV

Esophagitis caused by HSV

Esophagitis caused by tuberculosis

Other esophageal infections

Epidermolysis bullosa

Esophagitis in Crohn's disease

Chemotherapy and radiotherapy‐induced esophagitis

Final considerations

REFERENCES

21 Eosinophilic esophagitis

KEY POINTS

Introduction

Mucosal biopsy procurement

Assessment of esophageal gross findings

Therapeutic uses for endoscopy

Future alternative devices for mucosal assessment

Acknowledgments

REFERENCES

22 Gastritis and gastropathy

KEY POINTS

Introduction

Infective gastropathy

Reactive gastropathy

Conclusion

REFERENCES

23 Celiac disease

KEY POINTS

Introduction

Visual diagnosis, biopsy sampling, handling, and histopathology

Future of endoscopy in pediatric CD

REFERENCES

24 Role of endoscopy in inflammatory bowel disease including scoring systems

KEY POINTS

Introduction

Diagnosis

Monitoring

Scoring systems. Ulcerative colitis

Mayo score

Ulcerative Colitis Endoscopic Index of Severity (UCEIS)

Ulcerative Colitis Colonoscopic Index of Severity (UCCIS)

Crohn’s disease. Crohn’s Disease Endoscopic Index of Severity (CDEIS)

Simple Endoscopic Score for CD (SES‐CD)

Rutgeerts score

REFERENCES

25 Endoscopic management of esophageal strictures

KEY POINTS

Stricture presentation

Classification

Diagnosis

Differential diagnosis

Treatment. Bougie dilation

Balloon dilation

Adjunct therapies. Intralesional steroid injection

Mitomycin C

Incisional therapy

Esophageal stenting

Self‐expandable metal stents

Self‐expandable plastic stents

Biodegradable stents

Dynamic Stent

Outcome

REFERENCES

26 Endoscopic management of caustic ingestion

KEY POINTS

Introduction

Epidemiology

Pathophysiology

Clinical presentation

Assessment and management

Endoscopy

Treatment

Long‐term complications

REFERENCES

27 Pneumatic balloon dilation and peroral endoscopic myotomy for achalasia

KEY POINTS

Introduction

Diagnosis and management of achalasia

Therapeutic options

Pneumatic balloon dilation

Peroral endoscopic myotomy

REFERENCES

28 Endoscopic approaches to the treatment of gastroesophageal reflux disease

KEY POINTS

Introduction

Endoscopic suturing devices

EsophyX ®

Delivery of radiofrequency energy (Stretta® system)

Gastroesophageal biopolymer injection

Conclusion

FURTHER READING

29 Foreign body ingestion

KEY POINTS

Introduction

Diagnostic evaluation

Esophageal impaction of a foreign body

Foreign bodies in the stomach and small bowel

Batteries

Magnets

Drug packets

Food bolus impaction

Equipment and management approaches for foreign body removal

REFERENCES

30 Non‐variceal endoscopic hemostasis

KEY POINTS

Introduction

General considerations

Choice of endoscope

Techniques of endoscopic hemostasis

Epinephrine injection therapy

Endoscopic hemostatic powder and gel

Hemostatic clips

Over‐the‐scope clip

Thermal coagulation

Bipolar or multipolar thermal devices

Computer‐controlled thermal probes (heater probes)

Argon plasma coagulation (APC)

Technique of thermal coagulation

REFERENCES

31 Variceal endoscopic hemostasis

KEY POINTS

Portal hypertension and variceal formation

Diagnosis, classification, and risk stratification of varices

Primary prophylaxis

Acute bleeding

Hemospray®

Self‐expanding metal stents

Secondary prophylaxis

Gastric varices

REFERENCES

32 Endoscopic approach to obscure gastrointestinal bleeding lesions

KEY POINTS

Introduction

Classification

Evaluation and management of obscure gastrointestinal bleeding

Capsule endoscopy (CE)

Diagnostic and therapeutic approach with enteroscopy. Double‐balloon enteroscopy

Push enteroscopy

Intraoperative enteroscopy

Bleeding scans and other modalities

Conclusion

REFERENCES

33 Percutaneous endoscopic gastrostomy

KEY POINTS

Introduction

Indications

Contraindications

Decision to proceed with PEG and preprocedure evaluation

Technique. Personnel

Patient preparation

PEG insertion procedure

Postprocedure management

Complications

New uses of the PEG technique

Conclusion

FURTHER READING

34 Single‐stage percutaneous endoscopic gastrostomy

KEY POINTS

Introduction

Indications

Contraindications

Advantages of single‐stage PEG

Drawbacks

Technique. Personnel

Procedure. 1. Site identification

2. Marking the site

3. Placing of gastropexy

4. Creating the stoma tract

5. Dilation of the stoma tract and measuring the stoma length

6. Button placement

Postprocedure management

Complications

Useful tips

Materials

Consent

REFERENCES

35 Pediatric laparoscopic‐assisted direct percutaneous jejunostomy

KEY POINTS

Introduction

Conclusion

FURTHER READING

36 Naso‐jejunal and Gastro‐jejunal tube placement

KEY POINTS

FURTHER READING

37 Endoscopic retrograde cholangiopancreatography

KEY POINTS

Introduction

Duodenoscopes and accessories

Performing ERCP in children

Adverse events in pediatric ERCP

Biliary indications for diagnostic and therapeutic ERCP

Biliary atresia

Choledochal cysts

Choledocholithiasis

Primary sclerosing cholangitis

Postsurgical and posttraumatic biliary disease

Pancreatic indications for diagnostic and therapeutic ERCP

Acute pancreatitis

Recurrent pancreatitis

Anomalous pancreaticobiliary union

Pancreas divisum

Functional biliary sphincter disorder (previously sphincter of Oddi dysfunction; SOD)

Chronic pancreatitis

Pancreatic pseudocyst, necrosis, and trauma

EUS in pancreatitis

Duodenal duplication cyst

Conclusion

FURTHER READING

38 Endoscopic drainage of pancreatic pseudocysts

KEY POINTS

Pancreatitis

Pancreatic pseudocysts

REFERENCES

39 Duodenal web division by endoscopy

KEY POINTS

FURTHER READING

40 Polypectomy

KEY POINTS

Principles of electrosurgery

Snare loops

Routine polypectomy

Safety routine

Preparation and techniques

Complications

FURTHER READING

41 Endomucosal resection

KEY POINTS

Introduction

High‐magnification chromoscopic colonoscopy

Pit patterns

HMCC in the detection of intraepithelial neoplasia and colitis‐associated cancer

Summary of limitations of current imaging technology

Endoscopic mucosal resection

Basic EMR technique

Postresection management

Complications of EMR

Clinical recommendations and conclusions

42 Endoscopic management of polyposis syndromes

KEY POINTS

Introduction and classification

Familial adenomatous polyposis

Juvenile polyposis syndrome

Peutz–Jeghers syndrome

43 Transnasal gastrointestinal endoscopy

KEY POINTS

Introduction

Preendoscopy preparation

Views and image quality

Duration

Success rates

Patient comfort and preference

Complications and safety profile

Therapeutic use

Future considerations

Conclusion

REFERENCES

44 Endoscopic bariatric approaches

KEY POINTS

Introduction

Intragastric balloons

Duodenojejunal bypass liner

Conclusion

FURTHER READING

45 Over‐the‐scope clip and full‐thickness resection device

KEY POINTS

FURTHER READING

46 Endoscopic treatment of gastrointestinal bezoars

KEY POINTS

REFERENCES

47 Natural orifice transendoluminal surgery

KEY POINTS

Index. a

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c

d

e

f

g

h

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j

k

l

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n

o

p

q

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t

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Third Edition

.....

There is no ceiling to what we can achieve in pediatric endoscopy. Attending ‘adult’ GI and endoscopy meetings is illuminating e.g. ‘ESGE Days’. We are no longer the Cinderella part of pediatric GI but we still need to achieve parity with the adult Societies ‐ a place at the ‘top table’ i.e. Societal Councils – as occurs in all adult GI Societies.

I would like to thank all the trainees from so many countries and backgrounds for their personal commitment and sacrifice over the last 25 years in coming to train with us ‐ it never ceases to amaze me how mothers and fathers and spouses can leave their loved ones for months, on occasions a year or more, in order to train in this fantastic compelling area. Their ability to do so has been facilitated by my amazing Endoscopy Fellow and Course Coordinator, without whom it would have been truly impossible to run such a successful training program ‐ Sam Goult. Thankyou Sam.And then, if you have got this far then ‘well done’. It is so important to me to hold up my hand and say that, in all honesty, I could have not done all that I have done (admittedly a microcosm in the great scheme of things) without the forbearance and tolerance of my wife Kay and my exceptional and talented and kind daughters Ella, Jess and Flo. Incredible people and my driving force. I am sorry to you all for being away so much giving lectures and all that stuff when you were growing up and when you, Kay, were managing them so amazingly, almost single‐handedly. I would have done things differently if I had had the time again and know what I know now. Medicine as a job is not necessarily life, although some times it is difficult to see beyond the vocation.

.....

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