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Blood and Marrow Transplantation Long Term Management
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Страница 1
Table of Contents
List of Tables
List of Illustrations
Guide
Pages
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CHAPTER 1 Introduction to long‐term survivorship after hematopoietic cell transplantation
Background
Rapidly rising numbers of long‐term transplant survivors
Long‐term issues in long‐term survivors
Developing resources and a guide for long‐term survivors
Declaration of commercial interest
References
CHAPTER 2 International Blood and Marrow Registries: trends on long‐term data collection
Overview of the Role of Registries in HCT
Overview of Late Effects Data Collection through Registries Registry Strengths
Registry Challenges
Future of Data Collection in Survivorship
Center for International Blood and Marrow Transplant Research (CIBMTR)
Introduction to the registry
Data collection
Late effects specific data collection
Future plans
The Registry of the European Society for Blood and Marrow Transplantation (EBMT)
Introduction to the registry
Data collection
Late effects specific data collection
Future plans
Asia‐Pacific Blood and Marrow Transplant Group (APBMT)
Introduction of the registry
Data collection
Late effects specific data collection
Future plans
The Registry of the Eastern Mediterranean Blood and Marrow Transplantation Group (EMBMT)
Introduction to the registry
Data collection
Late Effects Specific Data Collection
Future plans
References
CHAPTER 3 Long‐term follow‐up program and transplant clinic setup
Introduction
Concept of long‐term survivorship
Late effects after HSCT
Timing and transition to long‐term survivorship care
The transition from pediatric to adult long‐term care
Long‐term follow‐up program
Long‐term follow‐up Clinic
Long‐term transplant team and the annual LTFU visit
Preparation of the visit
The LTFU visit
Post‐visit follow‐up
Recommendation for screening and preventive practices
Organizing a long‐term follow‐up clinic in resource‐limited countries
Essential need for a LTFU clinic in resource limited countries
Unique challenges for survivorship in the resource limited countries
References
CHAPTER 4 Telemedicine in patient care of long‐term transplant survivors
Introduction
Principles of telehealth Components of Telehealth
Practical applications for Telehealth
Legal, ethical and regulatory considerations for Telehealth
Reimbursement and financial considerations for Telehealth
Challenges to Telehealth adoption
What we know about current models for hct survivorship
Example of a LTFU telemedicine model
Future directions
References
CHAPTER 5 Long‐term follow‐up calendar
Introduction
Survivorship care plan
Schedule of the long‐term follow‐up visit
Screening and preventive recommendations
References
CHAPTER 6 Late effects post‐allogeneic hematopoietic stem cell transplantation
Introduction
Identification of late effects
Late effects Acute and chronic infections
Cutaneous complications
Oral/dental complications
Hepatic complications
Gastrointestinal complications
Genital complications
Renal complications
Ocular complications
Endocrine complications
Hypogonadism, fertility loss, pregnancy, and lactation issues
Musculoskeletal and bone complications
Pulmonary complications
Neurologic complications
Psychological and social complications
Sexual dysfunction
Subsequent hematologic malignancies
Very late effects Cardiovascular complications
Subsequent neoplasms
Future directions
Summary
References
CHAPTER 7 Late effects post‐autologous hematopoietic stem cell transplantation
Introduction
Pulmonary Complications
Cardiovascular Complications
Secondary Malignancies
Endocrine and Metabolic Complications Thyroid Dysfunction
Bone Complications
Gonadal Dysfunction
Kidney Complications
Infectious Complications
Quality of Life and Psychosocial Effects
Cognitive Dysfunction
Special Considerations in Lymphoma and Myeloma
Conclusion
References
CHAPTER 8 Long‐term follow‐up of children
Introduction
Common posttransplant screening and prevention guidelines
Engraftment
Iron overload
Chronic GVHD
Infection and immunity
Ocular
Oral/dental
Pulmonary
Cardiovascular or metabolic
Gastrointestinal or hepatic
Renal or genitourinary
Muscle or connective tissue
Bone
Skin
Endocrinopathies
Growth Hormone deficiency
Hypogonadism, pubertal delay and infertility
Thyroid dysfunction
Iatrogenic Cushing’s Syndrome and Adrenal insufficiency
Insulin Resistance and Diabetes Mellitus
Neurocognitive
Psychological and quality of life
Subsequent neoplasms (SMN)
Survivorship care plans
References
CHAPTER 9 Graft‐versus‐host disease and late effects after hematopoietic stem cell transplantation
Introduction
cGVHD and nonmalignant late effects Ocular effects [18]
Pulmonary effects [29,30]
Restrictive lung disease
Chronic obstructive lung disease
Complications of bones and joints [36] Avascular necrosis of bone (AVN)
Osteoporosis
Late cardiovascular complications [48]
Secondary Malignancies
Secondary leukemia after allogeneic HSCT
Lymphomas
Solid Tumors[53]
Pathogenesis
Skin and mucosal carcinoma and cGVHD
Thyroid carcinoma and cGVHD
References
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