Оглавление
Группа авторов. Current Perspectives in Kidney Diseases
Contributions to Nephrology
Current Perspectives in Kidney Diseases
Contents
Foreword. Present and Future of Acute and Chronic Kidney Disease
Extracorporeal Treatments in Patients with Acute Kidney Injury and Sepsis
Abstract
Introduction
S-AKI: Novel Pathogenic Mechanisms, Biomarkers of Tissue Injury and Promising Therapeutic Targets
Fluid Overload
New Biomarkers and Phenotypic Analysis of Cells in the Peripheral Blood
Extracorporeal Therapies in Patients with Sepsis-Associated AKI
Biological and Clinical Effects of Extracorporeal Treatments
Timing
Dose
Modality
Anticoagulation Strategies
Specific Extracorporeal Therapies for S-AKI
Antibiotic Dosing during RRT
Conclusions
References
Citrate Anticoagulation during Continuous Renal Replacement Therapy
Abstract
Introduction
Citrate: Mechanism of the Anticoagulant Action
RCA versus Heparin: Incidence of Bleeding
RCA and Circuit Life Span
Citrate: Anticoagulant and Buffer
Metabolic and Electrolyte Disarrangements Due to Citrate Anticoagulation
Monitoring Citrate Anticoagulation during CRRT
RCA in Patients with Liver Failure as a Safety Paradigm
Conclusion
References
Coupled Plasma Filtration Adsorption Application for Liver and Thyroid Toxins
Abstract
Introduction
Case Reports. Case 1
Case 2
Discussion. New CPFA Application: Liver Failure
New CPFA Application Thyrotoxicosis
Conclusions
References
Extracorporeal Sorbent Technologies: Basic Concepts and Clinical Application
Abstract
Introduction
Basic Principles
Sorbent Materials and Structure
Requirements for a Sorbent
Mechanism of Solute Adsorption in Porous Media
Biocompatibility of Sorbents
Rationale for the Use of Adsorption in Clinical Settings
Most Common Modalities of Utilization of Sorbents
Hemoperfusion
Coupled Plasma Filtration-Adsorption
Sorbent-Based Adjunctive Therapies for Sepsis
CytoSorbTM
Polymyxin-B-HP
Novel Applications of Sorbents. Lixelle Beta 2-Microglobulin Apheresis Column
Virus Removal by Lectin Affinity Plasmapheresis
HP for Sepsis-Induced Acute Lung Injury
Sorbent Technology in Wearable Artificial Kidney Devices
Conclusions
References
Development of the New Kibou® Equipment for Continuous Renal Replacement Therapy from Scratch to the Final Configuration
Abstract
Introduction
Kibou® Design: Features and Characteristics
In vitro and In vivo Evaluation
Staff Involved
General Evaluation
Hardware Evaluation
Software Evaluation (Bugs, GUI)
Alarm Simulation Phase
Fluid Balance Error
Staff Training
Prescription
RRT Disposables and Tubing Set
Collection of Treatment Data and Parameters
Statistical Analysis
Evaluation Results. In vitro Testing
In vivo Testing
Conclusions
Acknowledgements
References
Phosphate in Chronic Kidney Disease Progression
Abstract
Introduction
P Homeostasis in Humans: Nutritional Intake, Intestinal Absorption and Renal Excretion
Assessing Nutritional P Intake and P Balance: A Tough Goal in Research and Clinical Practice
P and Mortality: Mechanisms in Pills
Conclusions
References
Fibroblast Growth Factor 23: Mineral Metabolism and Beyond
Abstract
Physiology and Pathophysiology of Fibroblast Growth Factor 23
FGF23 and Clinical Outcomes in CKD and ESRD
FGF23 in Kidney Transplantation
Future Perspectives
References
Restenosis in Hemodialytic Fistulas and Chronic Kidney Disease-Associated Vascular Disease: Two Pathologies Driven by Metakaryotic Stem Cells
Abstract
Introduction
Vascular Stem Cells Dysfunction and CKD-Associated Vascular Disease
Vascular Stem Cells Over-Proliferation and IH
Metakaryotic Stem Cells
New and Emerging Histopathology: High-Resolution Microscopy and Cell Culture Techniques
Conclusions
Acknowledgments
References
Mycophenolate Mofetil: A Possible Alternative Treatment for IgA Nephropathy
Abstract
Introduction
Case Report
Discussion
References
Genetics and Autosomal Dominant Polycystic Kidney Disease Progression
Abstract
References
Expanded Hemodialysis: A New Therapy for a New Class of Membranes
Abstract
Introduction
Why a New Class of Membranes?
What Are the Target Retention Molecules?
“Expanded Hemodialysis”: A Way to Optimize the Use of HRO Membranes
Conclusions
References
Mathematical Model of Potassium Profiling in Chronic Dialysis
Abstract
Introduction
Method
Body Fluid Model
Solute Kinetics
Equations for Sodium and Potassium
Assignment of Model Parameters
Results
Discussion
References
Home Hemodialysis: What Is Old Is New Again
Abstract
Brief History
Why It Faded?
Now It Is Back
What Has Changed?
Outcomes
Advantages
Disadvantages
Barriers
The Future
Acknowledgement
Disclosure Statement
References
Treatment of Acute Antibody-Mediated Rejection
Abstract
Introduction
Case Report
Treatment of AMR
Considerations and Conclusions
References
Chronic Allograft Injury: An Overview of Pathogenesis and Treatment Strategies
Abstract
Introduction
Non-Immunological Factors. CNI Nephrotoxicity
Poor Quality Donor Grafts
Uncontrolled Hypertension
Other Causes
Immunological Causes
Glomerular Disease Recurrence
Infections (Viral/Bacterial)
Diagnosis of CAI
Prevention of CAI
Therapeutic Options of CAI
Recurrent Primary Glomerulonephritis
Conclusion
References
Looking into the Graft without a Biopsy: Biomarkers of Acute Rejection in Renal Transplantation
Abstract
Introduction
Biomarker Fundamentals
Quantifying Alloreactive Antibodies
Quantifying Memory B Cells
Flow Cytometry
Measuring Anti-HLA Antibodies in Supernatants of ex vivo Expanded mBC Cultures
Enzyme-Linked Immunosorbent Spot Assays
Measuring Alloreactive Memory T Cells
Alloreactive T-Cell ELISPOT Assay
Panel of Reactive T-Cells
Urine Biomarkers
C-X-C Motif Chemokine Ligand 9
Urinary RNA
Molecular Biomarkers
Cell Free-DNA
Future Directions and Conclusions
References
Author Index
Subject Index
