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Группа авторов. Acute Kidney Injury - Basic Research and Clinical Practice
Contributions to Nephrology
Acute Kidney Injury – Basic Research and Clinical Practice
Contents
Preface
Acute Kidney Injury: Diagnosis and Classification in Adults and Children
Abstract
Introduction
AKI Definition and Classification in Adult Patients
Serum Creatinine Criteria for AKI Diagnosis
UO Criteria for AKI Diagnosis
GFR, eGFR, and RFR
Additional Limitations of KDIGO Criteria for AKI Diagnosis
An Outlook to the Future: AKI Biomarkers and Subclinical AKI
AKI Definition and Classification in Children and Neonates
Conclusions
References
Acute Kidney Injury Risk Assessment
Abstract
Introduction
Quality Measurement and AKI Risk Assessment
The Methodology of Quality Measure in AKI Risk Assessment
Plan
Do
Study
Act
Existing Literature of Quality Measure in AKI Risk Assessment
Conclusions
References
Acute Kidney Injury Biomarkers: What Do They Tell Us?
Abstract
Introduction
SCr and Urine Output: The Problems
AKI Biomarkers
AKI Biomarkers in the Surgical Patient
Neutrophil Gelatinase-Associated Lipocalin
Interleukin 18
Urinary KIM-1
Liver Type Fatty Acid Binding Protein
IGFBP-7 and TIMP-2
Subclinical AKI: Dysfunction or Injury?
Can Biomarkers Be Used to Guide Therapy?
Conclusions
References
Acute Kidney Injury Recovery
Abstract
Defining AKI Recovery
Pathophysiology of AKI Recovery
AKI Recovery Patterns and Outcomes
Measuring AKI Recovery
Conclusion
References
Acute Kidney Injury to Chronic Kidney Disease Transition
Abstract
Introduction
Role of Kidney Resident Cells in AKI to CKD Transition
Chronic Inflammation: A Link between AKI and CKD
Mitochondrial Dysfunction
Epigenetic Changes during AKI
RAS Activation in AKI and CKD
Tissue and Cellular Senescence
Prevention of AKI-to-CKD Transition and Future Clinical Perspectives
Conclusions
References
Acute Kidney Injury and Big Data
Abstract
Introduction
AKI Diagnosis: The Fulcrum of EHR-Enabled Approaches
Clinical Risk Prediction: Pre-AKI State
AKI Alerting: The AKI State
Longitudinal AKI Care: The Post-AKI State
Conclusions
Acknowledgment
References
Quality Measures in Acute Kidney Injury Management
Abstract
Introduction
Current Quality of AKI Healthcare
Quality Measures in AKI Management
QMs in AKI Prevention
QMs in AKI Diagnosis
QMs in AKI Non-Dialytic Treatment
QMs in AKI Dialytic Treatment
QMs in AKI Long-Term Follow-Up
Current Potential Method to Improve Quality of AKI Healthcare. Professional Education and Guidelines Promotion
Electronic Data System
Early Referral of Nephrology
AKI Care Bundle [38]
Conclusion
References
Acute Kidney Injury and Information Technology
Abstract
Introduction
Evidence for Electronic Alerts in AKI
AKI Detection
Impact of e-Alerts on Processes of Care and Outcomes
E-Alerts in Drug Management
One Step Further – Electronic Alerts in Identification of Patients at Risk of AKI
Conclusions
References
Technology in Medicine: Moving Towards Precision Management of Acute Kidney Injury
Abstract
Introduction
Technological Advances and the AKI Diagnosis
Technological Advances and the Acute Renal Replacement Therapy Prescription
Technological Advances in Delivery and Monitoring of ARRT
Technological Advances and ARRT Know-How
Conclusions
References
The Burden of Acute Kidney Injury and Related Financial Issues
Abstract
Introduction
Epidemiology
Short-Term Complications of AKI. Direct Effects of AKI
Mortality
Respiratory Complications
Cardiac Complications
Hepatic Dysfunction
Neurological Complications
Risk of Infections
Long-Term Complications. Mortality
Chronic Kidney Disease
Cardiovascular Complications
Bone Fractures
Infections
Health Care-Related Costs
Conclusion
References
Pediatric Acute Kidney Injury
Abstract
Introduction
Definition and Staging
AKI Epidemiology and Outcomes
AKI Risk Factors: Kidney Dysfunction with other Underlying Illnesses
AKI Prevention and (Pharmacologic) Therapy
Renal Replacement Therapy
Conclusions
References
Acute Kidney Injury in Cardiac Surgery
Abstract
Improving Awareness of CSA-AKI. Incidence
Short- and Long-Term Outcome
Tools for Risk Assessment
Electronic Detection of CSA-AKI
Management of CSA-AKI. Drugs
Renal Replacement Therapy
When to Start
When to Stop
Adequacy of RRT
Precision CRRT
Conclusions
References
Acute Kidney Injury in Cancer Patients
Abstract
Introduction
Epidemiology
Risk Factors and Specific Causes for AKI
Drug-Related AKI in Cancer Patients
AKI Induced by Targeted Therapies
AKI Induced by ICIs
Contrast-Induced Nephropathy in Cancer Patients
Sepsis
Abdominal Compartment Syndrome
Hypercalcemia with Hemodynamic AKI and Acute Nephrocalcinosis
AKI in Multiple Myeloma and Other Hematological Malignancies
AKI in Hematopoietic Cell Transplantation
Tumor Lysis Syndrome
Thrombotic Micro-Angiopathies
AKI in Renal Cell Carcinoma and Urothelial Cancers
Conclusions
References
Acute Kidney Injury in the Geriatric Population
Abstract
Aging and AKI: Epidemiology and Etiologies
Susceptibility to AKI
Diagnosis of AKI in the Elderly
Therapeutic Issues in AKI
Prognosis of AKI in the Elderly
Prevention of AKI in the Elderly
Summary
References
Author Index
Subject Index
