Оглавление
Группа авторов. Metabolic Syndrome Consequent to Endocrine Disorders
Frontiers of Hormone Research
Metabolic Syndrome Consequent to Endocrine Disorders
Contents
Preface
Metabolic Syndrome in Hypopituitarism
Abstract
Hypopituitarism
The Metabolic Syndrome
Clinical Relevance of Metabolic Phenotype in Hypopituitarism
Prevalence of MetS in Patients with Hypopituitarism
Impact of GHD and GHRT on Components of MetS in Patients with Hypopituitarism
Dyslipidemia in GHD and Responses to GHRT
Glucose Metabolism and Insulin Resistance in GHD and Responses to GHRT
Changes in Body Composition: Visceral Obesity in GHD and Response to GHRT
Hypertension, Vascular Changes, Inflammatory Cardiovascular Risk Markers, and Hypofibrinolysis in Patients with GHD
Cardiac Function and Morphology
MetS and Fatty Liver Disease in Patients with GHD and Hypopituitarism
Impact of Other Hormone Deficiencies on MetS in Patients with Hypopituitarism. GC and Metabolic Phenotype
Thyroxin and Metabolic Phenotype
Sex Steroids and Metabolic Phenotype
Newer Data on Metabolic and Cardiovascular Outcome in Patients with Hypopituitarism on Long-Term GHRT
Conclusion
References
Metabolic Complications of Acromegaly
Abstract
Introduction
Abnormalities in Glucose Metabolism
Changes in Lipid Metabolism
Other Cardiometabolic Risk Factors in Acromegaly
Conclusions
References
Metabolic Syndrome in Hyperprolactinemia
Abstract
Metabolic Syndrome and Prolactin
Hyperprolactinemia
PRL, Pregnancy and Lactation
New Insights on MetS in HyperPRL
New Insights on MetS and Hypoprolactinemia
PRL and T2D
PRL and Hypertension
Adiponectin, Prolactinoma, and MetS
MetS, hyperPRL and Schizophrenia
Conclusion
References
Metabolic Syndrome in Thyroid Disease
Abstract
Introduction and Definitions
Epidemiological Data/Observational Studies
TH and MetS: Experimental Data
Hypothalamic Control of Lipid and Glucose Metabolism by TH
TH Action on Adipose Tissue
TH Action on Liver
TH Action on Glucose Metabolism via Action on Pancreatic β-Cells and Muscle
TH and Blood Pressure Regulation
Interventional Studies
TH Effects on BAT and Muscle Metabolism in Humans
TH Effects on Liver, Lipids, and Blood Pressure in Humans
TH and Weight in Humans
Therapeutic Potentials of Thyroid Hormone Mimetics
Summary
Disclosure Statement
References
Metabolic Syndrome in Parathyroid Diseases
Abstract
Introduction
Primary Hyperparathyroidism
Obesity
Impaired Glucose Tolerance and Diabetes
Dyslipidemia
Arterial Blood Hypertension
Metabolic Syndrome in Familial Forms of PHPT
Secondary Hyperparathyroidism. Metabolic Syndrome in Chronic Kidney Disease-Related Hyperparathyroidism
Metabolic Syndrome in Vitamin D Deficiency-Related Hyperparathyroidism
Pseudohypoparathyroidism
Hypoparathyroidism
Concluding Remarks and Open Questions
References
Metabolic Syndrome in Cushing’s Syndrome Patients
Abstract
Introduction
Adipose Tissue Changes
Pathomechanism
Adipose Tissue Endocrine Activity
The Adipose Tissue in CS Patients Following Cure
Liver Steatosis in CS
Glucose Metabolism Alterations
Pathomechanism
Management
Dyslipidemia
Pathomechanism
Management
Cardiovascular Changes. Hypertension
Pathomechanism
Management
Vascular Changes
Cardiac Morphology
Summary
Acknowledgment
References
Metabolic Complications in Adrenal Insufficiency
Abstract
Introduction
Treatment of AI
Adverse Effects of Replacement Therapy
Hypertension
Glucose Metabolism
Lipids and Body Weight
Summary and Future Prospects
References
Metabolic Syndrome in Polycystic Ovary Syndrome
Abstract
Prevalence of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome
The Strict Interplay between Insulin Resistance, Hyperinsulinemia, and PCOS
Impact of Obesity and Visceral Adiposity on the Development of the Metabolic Syndrome in Women with PCOS
Does a PCOS Secondary to Obesity Exist?
Diabetes in PCOS
The Metabolic Syndrome and the Cardiometabolic Risk in Women with PCOS
Androgen Excess and Its Role in the Metabolic Syndrome Associated with PCOS. Aberrant Visceral Fat
Glucose Intolerance States and T2D
Dyslipidemia
Hypertension
Conclusive Remarks and Future Perspectives
References
Metabolic Syndrome in Male Hypogonadism
Abstract
Introduction
Association between MetS and HG
Association between HG and Specific MetS Components
Association between MetS and Sexual Symptoms
Associations between MetS-Associated HG and Clinical Features
The Vicious Cycle between MetS and HG
Effect of MetS Treatment on HG
Effect of HG Treatment on MetS Features and Correlates
Conclusions
References
The Metabolic Syndrome in Central Hypogonadotrophic Hypogonadism
Abstract
Definitions, Diagnostics, and Etiologies: The Metabolic Syndrome
The Biochemical Signature of CH
Confirming the Etiology of CH
Human Disease Models Providing Insights into the Relationship between Metabolism and the Reproductive Axis
Treatment Modalities as a Model for Understanding the Relationship between MetS and Hypogonadism
The Effects of Bariatric Surgery on Metabolism and Sex Steroids
The Effect of TRT on MetS
Outstanding Questions and Future Directions
References
Author Index
Subject Index
