Оглавление
Группа авторов. Advances in Radiation Therapy
Progress in Tumor Research
Advances in Radiation Therapy
Contents
Preface
References
Principles and Developments in Cancer Immunotherapy and Approaches for Combination with Tumour Irradiation
Abstract
Historical Overview of Immunotherapy Development. Cancer Immunotherapy with Induced Erysipelas
Immunological Features in the “Hallmarks of Cancer”
Development of Ipilimumab
Cancer Immunotherapy Concepts. Checkpoint Inhibition
Cancer Vaccines
T Cell-Engaging Therapies
Immunocytokines
Other Immunotherapy Strategies
Challenges in Immunotherapy Development
Immunological Effects of Radiation, Rationale for Combination Therapies
Combination Concepts. Combination of Irradiation and Immune Checkpoint Inhibition
Antigen Release through Irradiation and Cancer Vaccines
T Cell Effects and T Cell-Engaging Therapy
Tumour Microenvironment and Cytokine-Based Therapies
Combination of Radiotherapy and Immunotherapy in the Clinic. Concepts for Clinical Combinations
Questions and Challenges
Conclusion
References
Imageable Biomarkers for Radiotherapy Response
Abstract
PET Imaging
Imageable Biomarkers. Imaging of Hypoxia
Hypoxia and Radioresistance
Causes of Hypoxia
Counteracting Hypoxia
PET-Based Hypoxia Imaging
Advantages and Disadvantages of PET-Based Hypoxia Imaging
MRI-Based Hypoxia Imaging
Imaging of Proliferation. Proliferation and Radioresistance
Causes of Accelerated Proliferation
Counteracting Radioresistance due to Proliferation
PET-Based Proliferation Imaging
The Future of Biomarker Imaging for Radiotherapy
References
Targeting Tumor Microenvironment and Metabolism to Overcome Radiation Resistance
Abstract
Role of the Tumor Microenvironment
Tumor Hypoxia
Tumor Vasculature, Stromal Compartment, and ECM
Tumor Microenvironment-Related Treatment Resistance
Tumor Vasculature-Related Treatment Resistance
Tumor Cell-Driven Treatment Resistance
Fibrotic Compartment-Linked Treatment Resistance
Immune-Driven Radiation Resistance
Targeting Microenvironment-Mediated Radioresistance
Targeting the Tumor Cell Compartment
Targeting Tumor Hypoxia: Hypoxic Radiosensitizers and Hypoxia-Activated Prodrugs
Targeting Tumor Vasculature and Vessel Development
Targeting Tumor Metabolism
Targeting the Fibrotic Compartment
References
Imaging for Target Volume Definition and Response Assessment in Lung Cancer
Abstract
Definition of GTV in Lung Cancer
Definition of the CTV in Lung Cancer
Emerging Applications of Imaging
Heterogeneity in the Normal Tissues
Response Assessment
Conclusions
References
Advances in Technology and Its Application: Radiotherapy Treatment Planning
Abstract
Trends in Radiotherapy Treatment Planning
Standardization, Navigation, Automation
Solution Space Navigation
Constrained Optimization, Templates, and Automatic Optimisation
Plan Quality Prediction
Diversification of Dose Prescription
Risk-Adaptive Dose Prescription and Clinical Optimization
Dose Painting
Functional Organ Sparing
Treatment of Geometrical Uncertainties
From Images to Patient Motion Models
Real-Time Planning and Quality Assurance
Robust Optimisation
Conclusion
References
Stereotactic Body Radiotherapy
Historical Overview and Definition of Stereotactic Body Radiotherapy
SBRT for Early-Stage NSCLC
SBRT for Inoperable Patients with Stage I NSCLC
Controversies in SBRT for Early-Stage NSCLC
High-Risk Situations for SBRT
Expanding the Indication for SBRT
SBRT for Oligo-Metastatic Lung Cancer. Definition of Oligo-Metastases
Evidence Supporting the Value of Radiotherapy in Oligo-Metastatic NSCLC
The Optimal Local Intervention to Treat Oligo-Metastatic Disease
Optimization of Radical Treatment in Oligo-Metastatic NSCLC
SBRT for Oligo-Progressive Lung Cancer. Definition of Oligo-Progression
Outcome of SBRT for Oligo-Progressive Lung Cancer
Conclusion
References
Clinical Rationale and Indications for Particle Therapy
Abstract
Central Nervous System Tumors. Gliomas and Meningiomas
Skull Base Cancer
Sarcoma
Head and Neck Cancer
Lung Cancer
Early-Stage NSCLC
Advanced-Stage NSCLC
Liver and Pancreatic Cancer. Hepatocellular Carcinoma
Pancreatic Cancer
Gastrointestinal Cancer. Esophagus Cancer
Rectal Cancer
Prostate Cancer
Gynecological Malignancies
Pediatric Cancer
Conclusion
References
Advances in Radiation Biology of Particle Irradiation
Abstract
DNA Damage and Repair
Hypoxia, Resistance, and New Approaches to Overcome It
Normal Tissue Tolerance and Implications for the RBE
Radiogenomics
Late Adverse Effects
Systemic Immune Response and Combined Treatments
Hypofractionation and SBRT
Conclusion
References
Preclinical Mouse Models for the Evaluation of Novel Techniques in Particle Therapy
Abstract
Preclinical Models for Particle Radiotherapy
Preclinical Evaluation for the Optimization of Carbon Ion Radiotherapy
Preclinical Evaluation of Spatial Fractionation for Particle Therapy
Preclinical Evaluation of Laser-Driven Particle Acceleration
References
Author Index
Subject Index
