Advances in Radiation Therapy

Advances in Radiation Therapy
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Описание книги

Developments in radiation oncology have been key to the tremendous progress made in the field in recent years. The combination of optimal systemic treatment and local therapy has resulted in continuing improved outcomes of cancer therapy. This progress forms the basis for current pre-clinical and clinical research which will strengthen the position of radiation oncology as an essential component of oncological care. This book summarizes recent advances in radiotherapy research and clinical patient care. Topics include radiobiology, radiotherapy technology, and particle therapy. Chapters cover a summary and analysis of recent developments in the search for biomarkers for precision radiotherapy, novel imaging possibilities and treatment planning, and advances in understanding the differences between photon and particle radiotherapy. Advances in Radiation Therapy is an invaluable source of information for scientists and clinicians working in the field of radiation oncology. It is also a relevant resource for those interested in the broad topic of radiotherapy in general.

Оглавление

Группа авторов. Advances in Radiation Therapy

Progress in Tumor Research

Advances in Radiation Therapy

Contents

Preface

References

Principles and Developments in Cancer Immunotherapy and Approaches for Combination with Tumour Irradiation

Abstract

Historical Overview of Immunotherapy Development. Cancer Immunotherapy with Induced Erysipelas

Immunological Features in the “Hallmarks of Cancer”

Development of Ipilimumab

Cancer Immunotherapy Concepts. Checkpoint Inhibition

Cancer Vaccines

T Cell-Engaging Therapies

Immunocytokines

Other Immunotherapy Strategies

Challenges in Immunotherapy Development

Immunological Effects of Radiation, Rationale for Combination Therapies

Combination Concepts. Combination of Irradiation and Immune Checkpoint Inhibition

Antigen Release through Irradiation and Cancer Vaccines

T Cell Effects and T Cell-Engaging Therapy

Tumour Microenvironment and Cytokine-Based Therapies

Combination of Radiotherapy and Immunotherapy in the Clinic. Concepts for Clinical Combinations

Questions and Challenges

Conclusion

References

Imageable Biomarkers for Radiotherapy Response

Abstract

PET Imaging

Imageable Biomarkers. Imaging of Hypoxia

Hypoxia and Radioresistance

Causes of Hypoxia

Counteracting Hypoxia

PET-Based Hypoxia Imaging

Advantages and Disadvantages of PET-Based Hypoxia Imaging

MRI-Based Hypoxia Imaging

Imaging of Proliferation. Proliferation and Radioresistance

Causes of Accelerated Proliferation

Counteracting Radioresistance due to Proliferation

PET-Based Proliferation Imaging

The Future of Biomarker Imaging for Radiotherapy

References

Targeting Tumor Microenvironment and Metabolism to Overcome Radiation Resistance

Abstract

Role of the Tumor Microenvironment

Tumor Hypoxia

Tumor Vasculature, Stromal Compartment, and ECM

Tumor Microenvironment-Related Treatment Resistance

Tumor Vasculature-Related Treatment Resistance

Tumor Cell-Driven Treatment Resistance

Fibrotic Compartment-Linked Treatment Resistance

Immune-Driven Radiation Resistance

Targeting Microenvironment-Mediated Radioresistance

Targeting the Tumor Cell Compartment

Targeting Tumor Hypoxia: Hypoxic Radiosensitizers and Hypoxia-Activated Prodrugs

Targeting Tumor Vasculature and Vessel Development

Targeting Tumor Metabolism

Targeting the Fibrotic Compartment

References

Imaging for Target Volume Definition and Response Assessment in Lung Cancer

Abstract

Definition of GTV in Lung Cancer

Definition of the CTV in Lung Cancer

Emerging Applications of Imaging

Heterogeneity in the Normal Tissues

Response Assessment

Conclusions

References

Advances in Technology and Its Application: Radiotherapy Treatment Planning

Abstract

Trends in Radiotherapy Treatment Planning

Standardization, Navigation, Automation

Solution Space Navigation

Constrained Optimization, Templates, and Automatic Optimisation

Plan Quality Prediction

Diversification of Dose Prescription

Risk-Adaptive Dose Prescription and Clinical Optimization

Dose Painting

Functional Organ Sparing

Treatment of Geometrical Uncertainties

From Images to Patient Motion Models

Real-Time Planning and Quality Assurance

Robust Optimisation

Conclusion

References

Stereotactic Body Radiotherapy

Historical Overview and Definition of Stereotactic Body Radiotherapy

SBRT for Early-Stage NSCLC

SBRT for Inoperable Patients with Stage I NSCLC

Controversies in SBRT for Early-Stage NSCLC

High-Risk Situations for SBRT

Expanding the Indication for SBRT

SBRT for Oligo-Metastatic Lung Cancer. Definition of Oligo-Metastases

Evidence Supporting the Value of Radiotherapy in Oligo-Metastatic NSCLC

The Optimal Local Intervention to Treat Oligo-Metastatic Disease

Optimization of Radical Treatment in Oligo-Metastatic NSCLC

SBRT for Oligo-Progressive Lung Cancer. Definition of Oligo-Progression

Outcome of SBRT for Oligo-Progressive Lung Cancer

Conclusion

References

Clinical Rationale and Indications for Particle Therapy

Abstract

Central Nervous System Tumors. Gliomas and Meningiomas

Skull Base Cancer

Sarcoma

Head and Neck Cancer

Lung Cancer

Early-Stage NSCLC

Advanced-Stage NSCLC

Liver and Pancreatic Cancer. Hepatocellular Carcinoma

Pancreatic Cancer

Gastrointestinal Cancer. Esophagus Cancer

Rectal Cancer

Prostate Cancer

Gynecological Malignancies

Pediatric Cancer

Conclusion

References

Advances in Radiation Biology of Particle Irradiation

Abstract

DNA Damage and Repair

Hypoxia, Resistance, and New Approaches to Overcome It

Normal Tissue Tolerance and Implications for the RBE

Radiogenomics

Late Adverse Effects

Systemic Immune Response and Combined Treatments

Hypofractionation and SBRT

Conclusion

References

Preclinical Mouse Models for the Evaluation of Novel Techniques in Particle Therapy

Abstract

Preclinical Models for Particle Radiotherapy

Preclinical Evaluation for the Optimization of Carbon Ion Radiotherapy

Preclinical Evaluation of Spatial Fractionation for Particle Therapy

Preclinical Evaluation of Laser-Driven Particle Acceleration

References

Author Index

Subject Index

Отрывок из книги

Vol. 44

Series Editor

.....

52Dudek AM, et al: Inducers of immunogenic cancer cell death. Cytokine Growth Factor Rev 2013;24:319–333.

53Galluzzi L, Kepp O, Kroemer G: Immunogenic cell death in radiation therapy. Oncoimmunology 2013;2:e26536.

.....

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