Оглавление
Группа авторов. Pancreatic Tumors
Monographs in Clinical Cytology
Pancreatic Tumors
Contents
Preface
Introduction to Pancreatic Pathology and Fine-Needle Aspiration Cytology
Abstract
Demographics of Pancreatic Tumors
Pancreatic Tumor Classification
History and Current Concepts of Fine-Needle Aspiration Cytology of Pancreatic Tumors
Accuracy of FNA in Pancreatic Tumors
Rapid On-Site Evaluation
Papanicolaou Society of Cytopathology Guidelines for Pancreatobiliary Cytology. Summary of the Guidelines
Recommendations for Clinical Evaluation, Imaging Studies, Indications for Cytologic Study, and Preprocedural Requirements for Pancreatic FNA
Techniques for Cytological Sampling of Pancreatic Lesions
Standardized Terminology and Nomenclature
FNA Biopsy Follow-Up and Treatment Options for Patients with Pancreatobiliary Lesions
Non-Diagnostic
Negative
Atypical
Neoplastic: Benign
Neoplastic: Other
Suspicious
Positive/Malignant
Utilization of Ancillary Studies in the Cytologic Diagnosis of Pancreatic Lesions
Algorithmic Approach to Cytological Evaluation of Pancreatic Masses
Disclosure Statement
References
Processing of Fine-Needle Aspiration Specimens from Pancreatic Lesions
Abstract
Processing of Cytology Samples from Pancreatic Solid Masses
Smears
Rapid On-Site Evaluation
Performing ROSE
Stains
Collection Media
Cell Blocks
Processing of Cytology Samples from Pancreatic Cystic Lesions
Next-Generation Biopsy Devices
Disclosure Statement
References
Imaging of Pancreatic Tumors
Abstract
Imaging Techniques
Approach to Imaging Evaluation
Solid Lesions
Cystic Lesions
Disclosure Statement
References
Normal Components and Contaminants
Abstract
Normal Anatomy
Normal Pancreatic Components. Ductal Cells
Cytology
Key Cytological Features
Acinar Cells
Cytology
Key Cytological Features
Islet Cells
Cytology
Key Cytological Features
Gastrointestinal Contaminant
Gastric Contaminant
Cytology
Key Cytological Features
Duodenal Contaminant
Cytology
Key Cytological Features
Squamous Cell Contaminant
Cytology
Key Cytological Features
Mesothelial Contaminant. Overview
Cytology
Key Cytological Features
Liver Contaminant. Hepatocytes
Cytology
Key Cytological Features
Bile Duct Cells
Cytology
Key Cytological Features
Disclosure Statement
References
Non-Neoplastic Masses of the Pancreas
Abstract
The Pancreatitides
Acute Pancreatitis
Key Cytologic Features
Ancillary Studies
Differential Diagnosis
Chronic Pancreatitis
Key Cytologic Features
Ancillary Studies
Differential Diagnosis
Autoimmune Pancreatitis
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Paraduodenal/Groove Pancreatitis
Key Cytological Features
Ancillary Studies
Differential Diagnosis of All the Pancreatitides
Recognizing AIP
Reactive Atypia versus Adenocarcinoma
Intrapancreatic Spleen
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Pancreatic Abscess
Key Cytological Features
Ancillary Testing
Differential Diagnosis
Disclosure Statement
References
Non-Neoplastic and Neoplastic Cysts of the Pancreas
Abstract
Multimodal Approach to Pancreatic Cyst Diagnosis
Clinical
Imaging
Cytological Evaluation
Ancillary Testing
Biochemical Analysis
Immunohistochemistry
Molecular
Non-Neoplastic Cysts. Ductal Retention Cyst
Key Cytological Features
Ancillary Testing
Differential Diagnosis
Pseudocyst
Key Cytological Features
Ancillary Testing
Differential Diagnosis
Squamoid Cyst of Pancreatic Ducts
Key Cytological Features
Ancillary Testing
Differential Diagnosis
Lymphoepithelial Cyst
Key Cytological Features
Ancillary Testing
Differential Diagnosis
Foregut Cyst
Key Cytological Features
Ancillary Testing
Differential Diagnosis
Neoplastic Cysts. Serous Cystadenoma
Key Cytological Features
Ancillary Studies
Differentia Diagnosis
Preinvasive Precursors
Mucinous Cystic Neoplasm
Key Cytological Features
Ancillary studies
Differential Diagnosis
Intraductal Papillary Mucinous Neoplasm
Key Cytological Features
Ancillary Testing
Differential Diagnosis of Mucinous Cysts
Intraductal Oncocytic Papillary Neoplasms
Key Cytological Features
Ancillary Testing
Differential Diagnosis
Solid Neoplasms with Cystic Degeneration
Non-Epithelial Cysts. Lymphangioma
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Reporting of Pancreatic Cysts
Disclosure Statement
References
Pancreatic Ductal Adenocarcinoma
Abstract
Clinical Presentation
Imaging Studies
Ductal Adenocarcinoma, Conventional Type
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Morphological Patterns or Variations of PDAC, Conventional Type
PDAC with Vacuolated Cell Pattern
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
PDAC with Foamy Gland Pattern (or Foamy Gland Adenocarcinoma)
Cytology
Key Cytological Findings
Ancillary Studies
Differential Diagnosis
Related Carcinomas
Adenosquamous Carcinoma
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Undifferentiated (Anaplastic) Carcinoma
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Undifferentiated Carcinoma with Osteoclast-Like Giant Cells
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Colloid (Mucinous Non-Cystic) Carcinoma
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Signet Ring Cell Carcinoma
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Medullary Carcinoma
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Hepatoid Carcinoma
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Oncocytic Carcinoma
Histology
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Disclosure Statement
References
Non-Ductal Tumors of the Pancreas
Abstract
Pancreatic Neuroendocrine Tumor
Clinical Presentation
Imaging Studies
Histology
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Poorly Differentiated NECs
Clinical Presentation
Histology
Cytology
Key Cytological Features
Large Cell NEC:
Ancillary Studies
Differential Diagnosis
Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms
Acinar Cell Carcinoma
Clinical Presentation
Imaging
Histology
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Mixed Acinar NECs
Solid Pseudopapillary Neoplasm
Clinical Presentation
Imaging
Histology
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Pancreatoblastoma
Clinical Presentation
Imaging
Histology
Cytology
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Disclosure Statement
References
Metastases, Secondary Tumors, and Lymphomas of the Pancreas
Abstract
Clinical and Imaging Presentation
Cytological Diagnosis of Pancreatic Metastases
Cytology and Ancillary Studies of Pancreatic Metastases from Solid Tumors
Renal Cell Carcinoma
Key Cytological Features
Ancillary Studies
Differential Diagnosis
Lung Cancer
Key Cytological Findings
Ancillary Studies
Differential Diagnosis
Gastrointestinal Adenocarcinomas
Key Cytological Findings
Ancillary Studies
Differential Diagnosis
Breast Carcinoma
Key Cytological Findings
Ancillary Studies
Differential Diagnosis
Gynecological Primaries
Key Pathological Findings
Ancillary Studies
Differential Diagnosis
Skin Primaries: Melanoma
Key Pathological Findings
Differential Diagnosis
Merkel Cell Carcinoma
Key Pathological Findings
Ancillary Studies
Differential Diagnosis
Less Common Carcinomas
Rare and Non-Epithelial Malignancies
Hematopoietic Malignancies. Overview
Key Pathological Findings
Ancillary Studies
Differential Diagnosis
Disclosure Statement
References
Mesenchymal Tumors of the Pancreas
Abstract
Fibroblastic and Myofibroblastic Tumors. Inflammatory Myofibroblastic Tumor
Histology
Cytology
Key Cytological Features
Solitary Fibrous Tumor
Histology
Cytology
Key Cytological Features
Schwannoma. Overview
Histology
Cytology
Key Cytological Features
Leiomyoma and Leiomyosarcoma. Overview
Histology
Cytology
Key Cytological Features
Tumors of Perivascular Epithelioid Cells. Overview
Histology
Cytology
Key Cytological Features
Gastrointestinal Stromal Tumors. Overview
Histology
Cytology
Key Cytological Features
Other Mesenchymal Tumors
Disclosure Statement
References
Author Index
Subject Index
