Polysaccharides

Polysaccharides
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Описание книги

This book provides the whole spectrum of polysaccharides from basic concepts to commercial market applications. Chapters cover various types of sources, classification, properties, characterization, processing, rheology and fabrication of polysaccharide-based materials and their composites and gels. The applications of polysaccharides include in cosmetics, food science, drug delivery, biomedicine, biofuel production, marine, packaging, chromatography and environmental remediation. It also reviews the fabrication of inorganic and carbon nanomaterials from polysaccharides. The book incorporates industrial applications and will fill the gap between the exploration works in the laboratory and viable applications in related ventures.

Оглавление

Группа авторов. Polysaccharides

Table of Contents

List of Tables

List of Illustrations

Guide

Pages

Polysaccharides. Properties and Applications

Preface

1. Natural Polysaccharides From Aloe vera L. Gel (Aloe barbadensis Miller): Processing Techniques and Analytical Methods

1.1 Introduction

1.1.1 Gel Composition from A. vera

1.2 Applications of A. vera Mucilaginous Gel or Fractions

1.3 Aloe vera Gel Processing

1.3.1 Obtaining Polysaccharide Fraction or Acemannan

1.4 Analytical Methods Applied. 1.4.1 Total Carbohydrates, Oligosaccharides, Acemannan and Free Sugars

1.4.2 Analytical Techniques

1.4.2.1 Chromatography Analysis

1.4.2.2 Infrared Spectroscopy (IR)

1.4.2.3 Nuclear Magnetic Resonance Spectroscopy

1.4.2.4 Mass Spectrometry

1.4.2.5 Ultraviolet–Visible Spectroscopy

1.4.2.6 Comprehensive Microarray Polymer Profiling

1.5 Conclusion

References

2. Cell Wall Polysaccharides

2.1 Introduction to Cell Wall

2.2 Plant Cell Wall Polysaccharides

2.2.1 Cellulose

2.2.2 Hemicellulose

2.2.2.1 Xyloglucan

2.2.2.2 Xylans

2.2.2.3 Mannans

2.2.3 Callose

2.2.4 Pectic Polysaccharides

2.2.4.1 Homogalacturonan (HG)

2.2.4.2 Arabinan

2.3 Algal Cell Wall Polysaccharides

2.3.1 Alginates

2.3.2 Sulfated Galactans

2.3.3 Fucoidans

2.4 Fungal Cell Wall Polysaccharides

2.4.1 Glucan

2.4.2 Chitin and Chitosan

2.5 Bacterial Cell Wall Polysaccharides

2.5.1 Peptidoglycan

2.5.2 Lipopolysaccharides

References

3. Marine Polysaccharides: Properties and Applications

3.1 Introduction

3.2 Polysaccharide Origins

3.3 Properties

3.3.1 Cellulose

3.3.2 Chitosan

3.3.3 Alginate

3.3.4 Carrageenan

3.3.5 Agar

3.3.6 Porphyran

3.3.7 Fucoidan

3.3.8 Ulvan

3.3.9 Exopolysaccharides From Microalgae

3.4 Applications of Polysaccharides

3.4.1 Biomedical Applications. 3.4.1.1 Cellulose

3.4.1.2 Chitosan

3.4.1.3 Alginate

3.4.2 Food Applications. 3.4.2.1 Cellulose

3.4.2.2 Chitosan

3.4.2.3 Alginates

3.4.2.4 Carrageenan

3.4.2.5 Agar

3.4.3 Pharmaceutical and Nutraceutical Applications. 3.4.3.1 Cellulose

3.4.3.2 Chitosan

3.4.3.3 Alginate

3.4.3.4 Carrageenan

3.4.3.5 Porphyran

3.4.3.6 Fucoidan

3.4.4 Agriculture

3.5 Conclusions

References

4. Seaweed Polysaccharides: Structure, Extraction and Applications

4.1 Introduction

4.1.1 Agar

4.1.2 Carrageenan

4.1.3 Alginate (Alginic Acid, Algin)

4.1.4 Fucoidan

4.1.5 Laminaran

4.1.6 Ulvan

4.2 Conclusion

References

5. Agars: Properties and Applications

5.1 History and Origin of Agar

5.1.1 Agarophytes Used in Agar Manufacturing

5.2 Physical Properties of Agar Producing Seaweeds

5.3 Agar Manufacturing

5.3.1 Types of Agar Manufacturing. 5.3.1.1 Freeze–Thaw Method

5.3.1.2 Syneresis Method

5.4 Structure of Agar

5.5 Heterogeneity of Agar

5.6 Physico-Chemical Characteristics of Agar

5.7 Chemical Characteristics of Agar

5.8 Factors Influencing the Characteristics of Agar

5.8.1 Techniques to Analyze the Fine Chemical Structure of Agar

5.8.2 Synergies and Antagonisms of Agar Gels

5.9 Uses of Agar in Various Sectors

5.9.1 Applications of Agar in Food Industry

5.9.2 Application of Agar in Harvesting Insects and Worms

5.9.3 Vegetable Tissue Culture Formulations

5.9.4 Culture Media for Microbes

5.9.5 Industrial Applications of Agar

5.10 Conclusion and Discussion

References

6. Biopolysaccharides: Properties and Applications

6.1 Structure and Classification of Biopolysaccharides

6.1.1 Structure

6.1.2 Classification

6.1.3 Structural Characterization Techniques

6.2 Uses and Applications of Biopolysaccharides

6.2.1 Functional Fibers

6.2.2 Biomedicine

6.2.2.1 Tissue Engineering

6.2.2.2 Wound Healing

6.2.2.3 Drug Loading and Delivery

6.2.2.4 Therapeutics

6.2.3 Cosmetics

6.2.4 Foods and Food Ingredients

6.2.5 Biofuels

6.2.6 Wastewater Treatment

6.2.7 Textiles

6.3 Conclusion

References

7. Chitosan Derivatives: Properties and Applications

7.1 Introduction

7.2 Properties of Chitosan Derivatives

7.2.1 Physiochemical Properties

7.2.2 Functional Properties

7.2.3 Biological Properties of Chitosan

7.3 Applications of Chitosan Derivatives

7.3.1 Anticancer Agents

7.3.2 Bone Tissue Material Formation

7.3.3 Wound Healing, Tissue Regeneration and Antimicrobial Resistance

7.3.4 Drug Delivery

7.3.5 Chromatographic Separations

7.3.6 Waste Management

7.3.7 Food Industry

7.3.8 In Cosmetics

7.3.9 In Paint as Antifouling Coatings

7.4 Conclusions

Acknowledgement

References

8. Green Seaweed Polysaccharides Inventory of Nador Lagoon in North East Morocco

8.1 Introduction

8.2 Nador Lagoon: Situation and Characteristics

8.3 Seaweed

8.4 Polysaccharides in Seaweed

8.5 Algae Polysaccharides in Nador Lagoon’s Seaweed

8.5.1 C. prolifera

8.5.1.1 Sulfated Galactans

8.5.2 U. rigida & E. intestinalis

8.5.2.1 Ulvan

8.5.3 C. adhaerens, C. bursa, C. tomentosum

8.5.3.1 Sulfated Arabinans

8.5.3.2 Sulfated Arabinogalactans

8.5.3.3 Mannans

8.6 Conclusion

References

9. Salep Glucomannan: Properties and Applications

9.1 Introduction

9.2 Production

9.3 Composition and Physicochemical Structure

9.4 Rheological Properties

9.5 Purification and Deacetylation

9.6 Food Applications

9.6.1 Beverage

9.6.2 Ice Cream and Emulsion Stabilizing

9.6.3 Edible Film/Coating

9.6.4 Gelation

9.7 Health Benefits

9.8 Conclusions and Future Trends

References

10. Exudate Tree Gums: Properties and Applications

10.1 Introduction

10.1.1 Gum Arabic

10.1.2 Gum Karaya

10.1.3 Gum Kondagogu

10.1.4 Gum Ghatti

10.1.5 Gum Tragacanth

10.1.6 Gum Olibanum

10.2 Nanobiotechnology Applications

10.3 Minor Tree Gums

10.4 Conclusions

Acknowledgment

References

11. Cellulose and its Derivatives: Properties and Applications

11.1 Introduction

11.2 Main Raw Materials

11.3 Composition and Chemical Structure of Lignocellulosic Materials

11.4 Cellulose: Chemical Backbone and Crystalline Formats

11.5 Cellulose Extraction. 11.5.1 Mechanical Methods

11.5.2 Chemical Methods

11.6 Cellulose Products and its Derivatives

11.7 Main Applications

11.8 Conclusion

References

12. Starch and its Derivatives: Properties and Applications

12.1 Introduction

12.2 Physicochemical and Functional Properties of Starch

12.2.1 Size, Morphology and Crystallinity of Starch Granules

12.2.2 Physical Properties due to Associated Lipids, Proteins and Phosphorus With Starch Granules

12.2.3 Solubility and Swelling Capacity of Starch

12.2.4 Gelatinization and Retrogradation of Starch

12.2.5 Birefringence and Glass Transition Temperature of Starch

12.2.6 Rheological and Thermal Properties of Starch

12.2.7 Transmittance and Opacity of Starch

12.2.8 Melt Processability of Starch

12.3 Modification of Starch

12.3.1 Physical Modification of Starch

12.3.2 Chemical Modification of Starch

12.3.3 Dual Modification of Starch

12.3.4 Enzymatic Modification of Starch

12.3.5 Genetic Modification of Starch

12.4 Application of Starch and its Derivatives

12.4.1 In Food Industry

12.4.2 In Paper Industry

12.4.3 Starch as Binders

12.4.4 In Detergent Products

12.4.5 As Biodegradable Thermoplastic Materials or Bioplastics

12.4.6 In Pharmaceutical and Cosmetic Industries

12.4.7 As Industrial Raw Materials

12.4.8 As Adsorbents for Environmental Applications

12.4.9 As Food Packaging Materials

12.4.10 In Drug Delivery

12.4.11 As Antimicrobial Films and Coatings

12.4.12 In Advanced Functional Materials

12.5 Conclusion

References

13. Crystallization of Polysaccharides

13.1 Introduction

13.2 Principles of Crystallization of Polysaccharides

13.3 Techniques for Crystallinity Measurement

13.4 Crystallization Behavior of Polysaccharides

13.4.1 Cellulose

13.4.2 Chitosan and Chitin

13.4.3 Starch

13.5 Polymer/Polysaccharide Crystalline Nanocomposites

13.6 Conclusion

References

14. Polysaccharides as Novel Materials for Tissue Engineering Applications

14.1 Introduction

14.2 Types of Scaffolds for Tissue Engineering

14.3 Biomaterials for Tissue Engineering

14.4 Polysaccharide-Based Scaffolds for Tissue Engineering

14.4.1 Alginate-Based Scaffolds

14.4.2 Chitosan-Based Scaffolds

14.4.3 Cellulose-Based Scaffolds

14.4.4 Dextran and Pullulan-Based Scaffolds

14.4.5 Starch-Based Scaffolds

14.4.6 Xanthan-Based Scaffolds

14.4.7 Glycosaminoglycans-Based Scaffolds

14.5 Current Challenges and Future Perspectives

Acknowledgements

References

15. Structure and Solubility of Polysaccharides

15.1 Introduction

15.2 Polysaccharide Structure and Solubility in Water

15.3 Solubility and Molecular Weight

15.4 Solubility and Branching

15.5 Polysaccharide Solutions

15.6 Conclusions

Acknowledgments

References

16. Polysaccharides: An Efficient Tool for Fabrication of Carbon Nanomaterials

16.1 Introduction

16.2 Aerogels

16.2.1 Plant and Bacterial Cellulose

16.2.2 Carbon Derived From Nanocrystalline Cellulose of Plant Origin

16.2.3 Carbon Aerogels Produced From Bacterial Cellulose

16.2.4 Chitosan and Sodium Alginate for Preparation of Carbon Aerogels

16.3 Graphene-Like Materials and Nanotubes Produced From Polysaccharides

16.4 Biocarbon Quantum Dots

16.5 Membranes Containing Carbon Nanoparticles Derived From Cellulose

16.6 Conclusions

References

17. Rheology and Structural Properties of Polysaccharides

17.1 Introduction

17.2 General Structural Features of Polysaccharides

17.3 Main Types of Polysaccharides and Their Structural Properties

17.4 Rheological Behavior of Polysaccharides

17.4.1 Semi-Diluted and Concentrated Solutions of Polysaccharides

17.4.2 Gels of Polysaccharides

17.4.3 Polysaccharide Liquid Crystals

17.5 Conclusions

References

18. Gums-Based Bionanostructures for Medical Applications

18.1 Plants and Their Bioactive Compounds

18.2 Natural Gums—Physicochemical Features

18.3 Sources of Natural Gums. 18.3.1 Exudate Gums

18.3.2 Mucilages

18.3.3 Seaweed Polysaccharides

18.3.4 Microbial Polysaccharides

18.3.5 Animal Polysaccharide

18.3.6 Other Sources of Polysaccharide Gums

18.4 Classification of Gums

18.4.1 According to the Charge

18.4.2 According to the Source

18.4.3 According to Shape

18.4.4 According to Monomeric Units in Chemical Structure

18.4.5 Semi-Synthetic Gums

18.5 Composition of Natural Gums

18.6 Extraction and Purification of Natural Gums

18.7 Modification and Hydrolysis of Natural Gums

18.8 Medical Applications of Gums-Based Bio-Nanostructures

18.8.1 Conductive Adhesive Properties and Pharmaceutical Applications

18.8.2 Application in Imaging and Cell Studies

18.8.3 Application in Sutures

18.8.4 Biomaterials for Implantation

18.9 Conclusions

References

19. Alginates: Properties and Applications

19.1 Introduction

19.2 Properties of Sodium Alginate (Na-Alg)

19.2.1 Thickening Property of Alginates

19.2.2 Gelling Property of Alginates

19.2.3 Film-Forming Property

19.2.4 Lipophilicity

19.2.5 Solubility

19.2.6 pH Sensitivity

19.3 Chemical Properties

19.4 Applications

19.4.1 Bone Tissue Engineering

19.4.2 Pharmaceutical Applications

19.4.2.1 Small Chemical Drug Delivery

19.4.2.2 Protein Delivery

19.4.3 Wound Dressing

19.4.4 Vaccine Delivery

19.4.5 Water Treatment Application

19.4.6 Alginate for Anion Removal

19.5 Conclusions and Prospects

Acknowledgments

Abbreviations

References

20. Marine Polysaccharides: Properties and Applications

20.1 Introduction

20.2 Marine Bacteria That Produce Polysaccharides

20.3 Marine Fungi That Produce Polysaccharide

20.4 Production, Extraction and Purification of Polysaccharides

20.4.1 Solid State Fermentation

20.4.2 Submerged Fermentation

20.4.3 Extraction and Purification of Polysaccharides

20.5 Characterization via Molecular, Biochemical and Cultural Characterization of Marine Polysaccharides

20.6 Conclusion and Future Recommendation to Knowledge

References

21. Polysaccharides: Promising Constituent for the Preparation of Nanomaterials

21.1 Introduction

21.1.1 Classification and Types of Nanomaterials

21.2 Preparation of Polysaccharide-Dependent Nanomaterials

21.2.1 Electrospinning

21.2.2 Dip Coating, Film Casting, and Physical Mixing

21.2.3 Layer by Layer Assembly

21.2.4 Ionotropic Gelation, Colloidal Assembly and Coprecipitation

21.2.5 In Situ NP Preparation

21.2.6 Ionotropic Gelation

21.3 Biocompatibility of Carbon-Based Nanomaterials

21.4 Conclusions and Summary

References

22. Anticancer Potential of Polysaccharides

22.1 Introduction

22.2 Mode of Action

22.2.1 Cell-Cycle Arrest

22.2.2 Receptor

22.2.3 Immunomodulatory Effect

22.2.4 Chemotherapy Enhancement

22.2.5 Mitochondrial Membrane Inhibition

22.2.6 Free Radicals Capture

22.3 Polysaccharides in Cancer Treatment

22.3.1 Lung Cancer

22.3.2 Blood Cancer

22.3.3 Liver Cancer

22.3.4 Gastric and Colon Cancer

22.3.5 Bladder and Kidney Cancer

22.3.6 Breast Cancer

22.3.7 Cervical Cancer

22.4 Polysaccharides in Conventional Therapies

22.4.1 Chemotherapy

22.4.2 Radiotherapy

22.4.3 Surgery

22.4.4 Phototherapy

22.4.5 Drug Delivery

22.4.6 Bioimaging

22.4.7 Food Supplement

22.5 Concluding Remarks and Future Trends

References

23. Polysaccharide-Based Membrane for Packaging Applications

23.1 Introduction

23.2 Polysaccharides as Biomaterials for Biodegradable Packaging

23.2.1 Polysaccharides Extracted From Animals. 23.2.1.1 Chitin and Chitosan

23.2.2 Polysaccharides Extracted From Plants. 23.2.2.1 Cellulose

23.2.2.2 Pectin

23.2.2.3 Starch

23.2.2.4 Galactomannans

23.2.3 Polysaccharides Extracted From Algae. 23.2.3.1 Carrageenan

23.2.3.2 Alginate

23.2.4 Polysaccharides Synthesized by Microorganisms. 23.2.4.1 Pullulan

23.2.4.2 Gellan Gum

23.2.4.3 Xanthan Gum

23.2.4.4 FucoPol

23.3 Properties of Polysaccharide-Based Packaging Film or Coating

23.3.1 Barrier Properties of Film or Coatings

23.3.2 Mechanical Properties of the Film

23.4 Polysaccharides-Based Nanocomposites Packaging

23.5 Polysaccharides-Based Films and Coatings in Food Packaging Applications

23.5.1 Food Preservation and Self-Life Extension

23.5.2 Antimicrobial Coating

23.5.3 Delaying of Post-Harvest Ripening

23.5.4 Restoring Color, Aroma and Nutritional Value

23.5.5 Antioxidant Properties

23.6 Conclusion and Prospects

References

24. Applications of Polysaccharides in Cancer Treatment

24.1 Introduction

24.2 Types of Polysaccharides Used in Cancer Treatment. 24.2.1 Animal Polysaccharides

24.2.2 Vegetal Polysaccharides

24.2.3 Microorganism and Fungi Polysaccharides

24.3 Mechanism of Polysaccharides as Anticancer Agent. 24.3.1 Actions of Polysaccharides as Immunological Functioning

24.3.2 Role of Polysaccharides in Cell Signaling

24.3.3 Effect of Polysaccharides in Apoptosis and Cell Cycle Arrest

24.3.4 Antitumor Effect of Polysaccharides

24.4 Usage of Polysaccharides in Preclinical and Clinical Models of Cancer. 24.4.1 In-Vitro Cell Line Model

24.4.2 Polysaccharides as Antitumor/Anticancer in Animal Model Study

24.4.3 Clinical Trials of Polysaccharides in Cancer Treatment

24.5 Conclusion and Future Perspectives

References

25. Application of Chitosan-Based Catalysts for Heterocycles Synthesis and Other Reactions

25.1 Introduction

25.2 Recent Research Reports. 25.2.1 Furans

25.2.2 Pyrazoles

25.2.3 Imidazoles

25.2.4 Oxazoles

25.2.5 Thiazoles

25.2.6 Triazoles

25.2.7 Tetrazoles

25.2.8 Pyridines

25.2.9 Quinolines

25.2.10 Pyrazines

25.2.11 Pyrimidines

25.2.12 Quinazolines

25.2.13 Phthalazines

25.2.14 Perimidines

25.2.15 Pyrans

25.2.16 Coumarins

25.2.17 Chromenes

25.2.18 Other Reactions. 25.2.18.1 Oxidations

25.2.18.2 Reductions

25.2.18.3 Coupling/Condensation Reactions

25.2.18.4 Isomerization

25.2.18.5 Ring Opening

25.3 Conclusion

References

26. Preparation and Applications of Polysaccharide-Based Composites

26.1 Introduction

26.2 Types

26.2.1 Cellulose

26.2.2 Starch

26.2.3 Glycogen

26.2.4 Chitin

26.2.5 Pectin

26.3 Importance

26.4 Fabrication and Applications of Polysaccharide-Inorganic-Based Composites

26.4.1 Cellulose–Inorganic Materials

26.4.2 Starch–Inorganic Materials

26.4.3 Pectin–Inorganic Materials

26.4.4 Chitin and Chitosan–Inorganic Materials

26.4.5 Polysaccharides–Metal Organic Frameworks

26.5 Recent Applications

26.6 Conclusion

References

27. Polysaccharide-Based Liquid Crystals

27.1 Introduction

27.2 Polysaccharides-Based Liquid Crystals

27.2.1 Cellulose-Based Liquid Crystals

27.2.2 Liquid Crystals From Cellulose Derivatives

27.2.3 Amylose-Based Liquid Crystals

27.2.4 Dextrin-Based Liquid Crystals

27.2.5 Chitin-Based Liquid Crystals

27.2.6 Schizophyllan-Based Liquid Crystals

27.3 Conclusion

References

28. Patents on Polysaccharide Applications

28.1 Introduction

28.2 Polysaccharides in Medical Application

28.3 Polysaccharides in Cosmetic Application

28.4 Polysaccharides in Battery Components

28.5 Polysaccharides in Paper Manufacture

28.6 Conclusion

References

29. Applications of Polysaccharides in Controlled Release Drug Delivery System

29.1 Introduction

29.2 Polysaccharides From Plant Sources and Their Derivatives. 29.2.1 Cellulose

29.2.2 Cellulose Derivatives

29.2.2.1 Cellulose Ethers

29.2.2.1.1 Hydroxy Propyl Cellulose (HPC)

29.2.2.1.2 Methyl Cellulose (MC)

29.2.2.1.3 Ethyl Cellulose (EC)

29.2.2.1.4 Hypromellose/Hydroxy Propyl Methyl Cellullose (HPMC)

29.2.2.1.5 Hydroxy Ethyl Cellulose (HEC)

29.2.2.1.6 Sodium Carboxy Methyl Cellulose (Na CMC)

29.2.2.2 Cellulose Esters. 29.2.2.2.1 Cellulose Acetate Phthalate (CAP)

29.2.2.2.2 Hydroxypropylmethyl Cellulose Phthalate (HPMCP)

29.2.2.2.3 Microcrystalline Cellulose (MCC)

29.2.3 Hemicellulose

29.2.3.1 Mannans

29.2.3.1.1 Linear Mannans

29.2.3.1.2 Galactomannan

29.2.3.1.2.1 GUAR GUM

29.2.3.1.2.2 LOCUST BEAN GUM

29.2.3.1.2.3 FENUGREEK GUM

29.2.3.1.2.4 TARA GUM

29.2.3.1.3 Galacto-Glucomannan

29.2.3.1.4 Glucomannan

29.2.3.1.4.1 Konjac Mannan

29.2.4 Starch

29.2.5 Pectin

29.2.6 Lignin

29.2.7 Inulin

29.3 Gums

29.3.1 Exudate Gums. 29.3.1.1 Gum Arabic (Gum Acacia)

29.3.1.2 Gum Tragacanth

29.3.1.3 Gum Karaya

29.3.2 Mucilage Gums. 29.3.2.1 Okra Gum

29.3.2.2 Khaya Gum

29.3.2.3 Hakea Gum

29.3.2.4 Cassia tora Gum

29.3.2.5 Albizia Gum

29.3.2.6 Prunus cerasoides Gum

29.3.2.7 Tamarind Gum

29.3.2.8 Cissus populnea Gum

29.4 Polysaccharides From Algal Sources

29.4.1 Alginates

29.4.2 Galactans

29.4.3 Carrageenan

29.4.4 Agar

29.4.5 Agarose

29.5 Polysaccharides From Fungal Sources

29.5.1 Scleroglucan

29.5.2 Beta-Glucan

29.5.3 Pullulan

29.6 Polysaccharides From Animals Sources and Their Derivatives. 29.6.1 Chitin

29.6.2 Chitosan

29.6.3 Hyaluronic Acid

29.6.4 Glycogen

29.6.5 Chondroitin Sulfate

29.6.6 Dermatan Sulfate

29.6.7 Gelatin

29.7 Polysaccharides From Microorganisms

29.7.1 Curdlan

29.7.2 Xanthan Gum

29.7.3 Gellan Gum

References

30. Applications of Polysaccharides in Nutrition and Medicine

30.1 Introduction

30.2 Sources of Polysaccharides

30.2.1 Polysaccharides in Dietary Fibers

30.2.2 Polysaccharides in Plants

30.2.3 Polysaccharides in Algae and Lichens

30.2.4 Polysaccharides in Fungi

30.2.5 Polysaccharides From Bacteria

30.2.6 Polysaccharides From Other Sources

30.3 Role of Polysaccharides in Nutrition. 30.3.1 Polysaccharides in Food

30.3.2 Polysaccharides as Energy Sources

30.3.3 Health Impact of Polysaccharides

30.3.4 Nutritional Aspect of Polysaccharides

30.4 Biomedical Applications of Polysaccharides. 30.4.1 Polysaccharides as Antimicrobial and Antiviral

30.4.2 Polysaccharides as Antitumor/Anticancer

30.4.3 Polysaccharides as Anti-Obesity and Anti-Hypercholesterolemic Agents

30.4.4 Polysaccharides as Antidiabetic Agents

30.4.5 Polysaccharides as Immune Modulator Agent

30.4.6 Polysaccharides as Anti-Inflammatory Agent

30.4.7 Polysaccharides as Neuro-Protective Agent

30.4.8 Polysaccharides as a Source of Antioxidant

30.4.9 Polysaccharides in Wound Healing and Wound Dressing

30.5 Conclusion

References

31. Synthetic Polysaccharide-Based Vaccines: Progress and Achievements

31.1 A Brief History of Vaccination

31.2 The Leverage of Synthetic Polysaccharide-Based Vaccines Over Natural Polysaccharide-Based Vaccines

31.3 The Principles of Synthetic Polysaccharide-Based Vaccines

31.3.1 Tumor Vaccines

31.3.2 Leishmaniasis Vaccines

31.3.3 Human Immunodeficiency Virus Vaccines

31.3.4 Bacterial Vaccines

31.4 The Opportunities and Prospects of Synthetic Polysaccharide-Based Vaccine Technologies

References

32. Polysaccharides Derived From Natural Sources: A Panacea to Health and Nutritional Challenges

32.1 Introduction

32.2 Different Types of Polysaccharides Derived From Different Natural Sources

32.2.1 Polysaccharides Derived From Plants and Their Applications

32.2.2 Animal Derived Polysaccharides and Their Applications

32.2.2.1 Chitosan and Chitin

32.2.2.2 Heparin and Heparin Sulfates

32.2.2.3 Hyaluronic Acid

32.2.3 Microorganisms Derived Polysaccharides and Their Applications

32.2.3.1 Alginate

32.2.3.2 Dextran

32.2.3.3 Fucoidans

32.2.3.4 Spirulina

32.2.4 Homoglycans

32.2.4.1 Starch and Hetastarch

32.2.4.2 Cellulose

32.2.4.3 Inulin

32.2.4.4 Chitin and Chitosan

32.2.4.5 Glycogen

Glycogen, the Storage Form of Glucose in Tissues

32.2.4.6 Heteroglycans and Other Polysaccharides

32.2.4.7 Glycosaminoglycans Significance

32.2.4.8 Chondroitin Sulfates

32.2.4.9 Hyaluronic Acid

32.2.4.10 Alginic Acid

32.2.4.11 Mucopolysaccharidoses

32.3 Production, Extraction and Purification of Polysaccharides

32.3.1 Solid State Fermentation

32.3.2 Submerged Fermentation

32.3.3 Extraction and Purification Process of Polysaccharides

32.4 Specific Examples of Polysaccharides and Their Various Applications in Nutrition and Medicine

32.4.1 Schizophyllan

32.4.1.1 Antitumor Activity of Schizophyllan

32.4.1.2 Anti-Inflammatory Activity of Schizophyllan

32.4.1.3 Immunomodulatory Activity of Schizophyllan

32.4.1.4 Prebiotic Potential of Schizophyllan

32.4.2 Pleuran and Others Polysaccharides From Pleurotus spp

32.4.2.1 Specific Nutritional and Beneficial Functions of Pleurotus Polysaccharides

32.4.3 Scleroglucan

32.4.3.1 Applications for Nutritional and Medicinal Purposes Derived From Scleroglucan

32.4.4 Curdlan

32.4.5 Other Essential Polysaccharides With Medical Significance

32.5 Conclusion and Recommendation to Knowledge

References

Index

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52. Koga, A.Y., Pereira, A.V., Lipinski, L.C., Oliveira, M.R.P., Evaluation of wound healing effect of alginate films containing Aloe vera (Aloe barbadensis Miller) gel. J. Biomater. Appl., 32, 9, 1212–21, 2018.

53. Ranjbar-Mohammadi, M., Characteristics of aloe vera incorporated poly(ε-caprolactone)/gum tragacanth nanofibers as dressings for wound care. J. Ind. Text., 47, 7, 1464–77, 2018.

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