Biomedical Data Mining for Information Retrieval

Biomedical Data Mining for Information Retrieval
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This book comprehensively covers the topic of mining biomedical text, images and visual features towards information retrieval. Biomedical and Health Informatics is an emerging field of research at the intersection of information science, computer science, and health care and brings tremendous opportunities and challenges due to easily available and abundant biomedical data for further analysis. The aim of healthcare informatics is to ensure the high-quality, efficient healthcare, better treatment and quality of life by analyzing biomedical and healthcare data including patient's data, electronic health records (EHRs) and lifestyle. Previously it was a common requirement to have a domain expert to develop a model for biomedical or healthcare; however, recent advancements in representation learning algorithms allows us to automatically to develop the model. Biomedical Image Mining, a novel research area, due to its large amount of biomedical images increasingly generates and stores digitally. These images are mainly in the form of computed tomography (CT), X-ray, nuclear medicine imaging (PET, SPECT), magnetic resonance imaging (MRI) and ultrasound. Patients' biomedical images can be digitized using data mining techniques and may help in answering several important and critical questions related to health care. Image mining in medicine can help to uncover new relationships between data and reveal new useful information that can be helpful for doctors in treating their patients.

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Группа авторов. Biomedical Data Mining for Information Retrieval

Table of Contents

Guide

List of Illustrations

List of Tables

Pages

Biomedical Data Mining for Information Retrieval. Methodologies, Techniques and Applications

Preface. Introduction

Organization of the Book

Concluding Remarks

1. Mortality Prediction of ICU Patients Using Machine Learning Techniques

1.1 Introduction

1.2 Review of Literature

1.3 Materials and Methods. 1.3.1 Dataset

1.3.2 Data Pre-Processing

1.3.3 Normalization

1.3.4 Mortality Prediction

1.3.5 Model Description and Development

1.4 Result and Discussion

1.5 Conclusion

1.6 Future Work

References

2. Artificial Intelligence in Bioinformatics

2.1 Introduction

2.2 Recent Trends in the Field of AI in Bioinformatics

2.2.1 DNA Sequencing and Gene Prediction Using Deep Learning

2.3 Data Management and Information Extraction

2.4 Gene Expression Analysis

2.4.1 Approaches for Analysis of Gene Expression

2.4.2 Applications of Gene Expression Analysis

2.5 Role of Computation in Protein Structure Prediction

2.6 Application in Protein Folding Prediction

2.7 Role of Artificial Intelligence in Computer-Aided Drug Design

2.8 Conclusions

References

3. Predictive Analysis in Healthcare Using Feature Selection

3.1 Introduction

3.1.1 Overview and Statistics About the Disease. 3.1.1.1 Diabetes

3.1.1.2 Hepatitis

3.1.2 Overview of the Experiment Carried Out

3.2 Literature Review. 3.2.1 Summary

3.2.2 Comparison of Papers for Diabetes and Hepatitis Dataset

3.3 Dataset Description. 3.3.1 Diabetes Dataset

3.3.2 Hepatitis Dataset

3.4 Feature Selection

3.4.1 Importance of Feature Selection

3.4.2 Difference Between Feature Selection, Feature Extraction and Dimensionality Reduction

3.4.3 Why Traditional Feature Selection Techniques Still Holds True?

3.4.4 Advantages and Disadvantages of Feature Selection Technique. 3.4.4.1 Advantages

3.4.4.2 Disadvantage

3.5 Feature Selection Methods

3.5.1 Filter Method

3.5.1.1 Basic Filter Methods

3.5.1.2 Correlation Filter Methods

3.5.1.3 Statistical & Ranking Filter Methods

3.5.1.4 Advantages and Disadvantages of Filter Method

3.5.2 Wrapper Method

3.5.2.1 Advantages and Disadvantages of Wrapper Method

3.5.2.2 Difference Between Filter Method and Wrapper Method

3.6 Methodology

3.6.1 Steps Performed

3.6.2 Flowchart

3.7 Experimental Results and Analysis

3.7.1 Task 1—Application of Four Machine Learning Models

3.7.2 Task 2—Applying Ensemble Learning Algorithms

3.7.3 Task 3—Applying Feature Selection Techniques

3.7.4 Task 4—Appling Data Balancing Technique

3.8 Conclusion

References

4. Healthcare 4.0: An Insight of Architecture, Security Requirements, Pillars and Applications

4.1 Introduction

4.2 Basic Architecture and Components of e-Health Architecture

4.2.1 Front End Layer

4.2.2 Communication Layer

4.2.3 Back End Layer

4.3 Security Requirements in Healthcare 4.0

4.3.1 Mutual-Authentications

4.3.2 Anonymity

4.3.3 Un-Traceability

4.3.4 Perfect—Forward—Secrecy

4.3.5 Attack Resistance

4.3.5.1 Replay Attack

4.3.5.2 Spoofing Attack

4.3.5.3 Modification Attack

4.3.5.4 MITM Attack

4.3.5.5 Impersonation Attack

4.4 ICT Pillar’s Associated With HC4.0

4.4.1 IoT in Healthcare 4.0

4.4.2 Cloud Computing (CC) in Healthcare 4.0

4.4.3 Fog Computing (FC) in Healthcare 4.0

4.4.4 BigData (BD) in Healthcare 4.0

4.4.5 Machine Learning (ML) in Healthcare 4.0

4.4.6 Blockchain (BC) in Healthcare 4.0

4.5 Healthcare 4.0’s Applications-Scenarios

4.5.1 Monitor-Physical and Pathological Related Signals

4.5.2 Self-Management, and Wellbeing Monitor, and its Precaution

4.5.3 Medication Consumption Monitoring and Smart-Pharmaceutics

4.5.4 Personalized (or Customized) Healthcare

4.5.5 Cloud-Related Medical Information’s Systems

4.5.6 Rehabilitation

4.6 Conclusion

References

5. Improved Social Media Data Mining for Analyzing Medical Trends

5.1 Introduction. 5.1.1 Data Mining

5.1.2 Major Components of Data Mining

5.1.3 Social Media Mining

5.1.4 Clustering in Data Mining

5.2 Literature Survey

5.3 Basic Data Mining Clustering Technique

5.3.1 Classifier and Their Algorithms in Data Mining

5.4 Research Methodology

5.5 Results and Discussion. 5.5.1 Tool Description

5.5.2 Implementation Results

5.5.3 Comparison Graphs Performance Comparison

5.6 Conclusion & Future Scope

References

6. Bioinformatics: An Important Tool in Oncology

6.1 Introduction

6.2 Cancer—A Brief Introduction

6.2.1 Types of Cancer

6.2.2 Development of Cancer

6.2.3 Properties of Cancer Cells

6.2.4 Causes of Cancer

6.3 Bioinformatics—A Brief Introduction

6.4 Bioinformatics—A Boon for Cancer Research

6.5 Applications of Bioinformatics Approaches in Cancer

6.5.1 Biomarkers: A Paramount Tool for Cancer Research

6.5.2 Comparative Genomic Hybridization for Cancer Research

6.5.3 Next-Generation Sequencing

6.5.4 miRNA

6.5.5 Microarray Technology

6.5.6 Proteomics-Based Bioinformatics Techniques

6.5.7 Expressed Sequence Tags (EST) and Serial Analysis of Gene Expression (SAGE)

6.6 Bioinformatics: A New Hope for Cancer Therapeutics

6.7 Conclusion

References

7. Biomedical Big Data Analytics Using IoT in Health Informatics

7.1 Introduction

7.2 Biomedical Big Data

7.2.1 Big EHR Data

7.2.2 Medical Imaging Data

7.2.3 Clinical Text Mining Data

7.2.4 Big OMICs Data

7.3 Healthcare Internet of Things (IoT)

7.3.1 IoT Architecture

7.3.2 IoT Data Source

7.3.2.1 IoT Hardware

7.3.2.2 IoT Middleware

7.3.2.3 IoT Presentation

7.3.2.4 IoT Software

7.3.2.5 IoT Protocols

7.4 Studies Related to Big Data Analytics in Healthcare IoT

7.5 Challenges for Medical IoT & Big Data in Healthcare

7.6 Conclusion

References

8. Statistical Image Analysis of Drying Bovine Serum Albumin Droplets in Phosphate Buffered Saline

8.1 Introduction

8.2 Experimental Methods

8.3 Results. 8.3.1 Temporal Study of the Drying Droplets

8.3.2 FOS Characterization of the Drying Evolution

8.3.3 GLCM Characterization of the Drying Evolution

8.4 Discussions. 8.4.1 Qualitative Analysis of the Drying Droplets and the Dried Films

8.4.2 Quantitative Analysis of the Drying Droplets and the Dried Films

8.5 Conclusions

Acknowledgments

References

9. Introduction to Deep Learning in Health Informatics

9.1 Introduction

9.1.1 Machine Learning v/s Deep Learning

9.1.2 Neural Networks and Deep Learning

9.1.3 Deep Learning Architecture

9.1.3.1 Deep Neural Networks

9.1.3.2 Convolutional Neural Networks

9.1.3.3 Deep Belief Networks

9.1.3.4 Recurrent Neural Networks

9.1.3.5 Deep Auto-Encoder

9.1.4 Applications

9.2 Deep Learning in Health Informatics. 9.2.1 Medical Imaging

9.2.1.1 CNN v/s Medical Imaging

9.2.1.2 Tissue Classification

9.2.1.3 Cell Clustering

9.2.1.4 Tumor Detection

9.2.1.5 Brain Tissue Classification

9.2.1.6 Organ Segmentation

9.2.1.7 Alzheimer’s and Other NDD Diagnosis

9.3 Medical Informatics

9.3.1 Data Mining

9.3.2 Prediction of Disease

9.3.3 Human Behavior Monitoring

9.4 Bioinformatics

9.4.1 Cancer Diagnosis

9.4.2 Gene Variants

9.4.3 Gene Classification or Gene Selection

9.4.4 Compound–Protein Interaction

9.4.5 DNA–RNA Sequences

9.4.6 Drug Designing

9.5 Pervasive Sensing

9.5.1 Human Activity Monitoring

9.5.2 Anomaly Detection

9.5.3 Biological Parameter Monitoring

9.5.4 Hand Gesture Recognition

9.5.5 Sign Language Recognition

9.5.6 Food Intake

9.5.7 Energy Expenditure

9.5.8 Obstacle Detection

9.6 Public Health

9.6.1 Lifestyle Diseases

9.6.2 Predicting Demographic Information

9.6.3 Air Pollutant Prediction

9.6.4 Infectious Disease Epidemics

9.7 Deep Learning Limitations and Challenges in Health Informatics

References

10. Data Mining Techniques and Algorithms in Psychiatric Health: A Systematic Review

10.1 Introduction

10.2 Techniques and Algorithms Applied

10.3 Analysis of Major Health Disorders Through Different Techniques. 10.3.1 Alzheimer

10.3.2 Dementia

10.3.3 Depression

10.3.4 Schizophrenia and Bipolar Disorders

10.4 Conclusion

References

11. Deep Learning Applications in Medical Image Analysis

11.1 Introduction

11.1.1 Medical Imaging

11.1.2 Artificial Intelligence and Deep Learning

11.1.3 Processing in Medical Images

11.2 Deep Learning Models and its Classification

11.2.1 Supervised Learning

11.2.1.1 RNN (Recurrent Neural Network)

11.2.2 Unsupervised Learning

11.2.2.1 Stacked Auto Encoder (SAE)

11.2.2.2 Deep Belief Network (DBN)

11.2.2.3 Deep Boltzmann Machine (DBM)

11.2.2.4 Generative Adversarial Network (GAN)

11.3 Convolutional Neural Networks (CNN)—A Popular Supervised Deep Model

11.3.1 Architecture of CNN

11.3.2 Learning of CNNs

11.3.3 Medical Image Denoising using CNNs

11.3.4 Medical Image Classification Using CNN

11.4 Deep Learning Advancements—A Biological Overview

11.4.1 Sub-Cellular Level

11.4.2 Cellular Level

11.4.3 Tissue Level

11.4.4 Organ Level

11.4.4.1 The Brain and Neural System

11.4.4.2 Sensory Organs—The Eye and Ear

11.4.4.3 Thoracic Cavity

11.4.4.4 Abdomen and Gastrointestinal (GI) Track

11.4.4.5 Other Miscellaneous Applications

11.5 Conclusion and Discussion

References

12. Role of Medical Image Analysis in Oncology

12.1 Introduction

12.2 Cancer

12.2.1 Types of Cancer

12.2.2 Causes of Cancer

12.2.3 Stages of Cancer

12.2.4 Prognosis

12.3 Medical Imaging

12.3.1 Anatomical Imaging

12.3.2 Functional Imaging

12.3.3 Molecular Imaging

12.4 Diagnostic Approaches for Cancer

12.4.1 Conventional Approaches

12.4.1.1 Laboratory Diagnostic Techniques

12.4.1.2 Tumor Biopsies

12.4.1.3 Endoscopic Exams

12.4.2 Modern Approaches

12.4.2.1 Image Processing

12.4.2.2 Implications of Advanced Techniques

12.4.2.3 Imaging Techniques

12.5 Conclusion

References

13. A Comparative Analysis of Classifiers Using Particle Swarm Optimization-Based Feature Selection

13.1 Introduction

13.2 Feature Selection for Classification. 13.2.1 An Overview: Data Mining

13.2.2 Classification Prediction

13.2.3 Dimensionality Reduction

13.2.4 Techniques of Feature Selection

13.2.5 Feature Selection: A Survey

13.2.6 Summary

13.3 Use of WEKA Tool. 13.3.1 WEKA Tool

13.3.2 Classifier Selection

13.3.3 Feature Selection Algorithms in WEKA

13.3.4 Performance Measure

13.3.5 Dataset Description

13.3.6 Experiment Design

13.3.7 Results Analysis

13.3.8 Summary

13.4 Conclusion and Future Work. 13.4.1 Summary of the Work

13.4.2 Research Challenges

13.4.3 Future Work

References

Index

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27. Ng, A. and Si, D., Beta-Barrel Detection for Medium Resolution CryoElectron Microscopy Density Maps Using Genetic Algorithms and Ray Tracing. J. Comput. Biol., 25, 6, 326–336, 2018.

28. Li, R., Si, D., Zeng, T., Ji, S., He, J., Deep Convolutional Neural Networks for Detecting Secondary Structures in Protein Density Maps from Cryo-Electron Microscopy. Proceedings, pp. 41–46, 2016.

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