The Power of Plagues

The Power of Plagues
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The Power of Plagues presents a rogues' gallery of epidemic- causing microorganisms placed in the context of world history. Author Irwin W. Sherman introduces the microbes that caused these epidemics and the people who sought (and still seek) to understand how diseases and epidemics are managed. What makes this book especially fascinating are the many threads that Sherman weaves together as he explains how plagues past and present have shaped the outcome of wars and altered the course of medicine, religion, education, feudalism, and science. Cholera gave birth to the field of epidemiology. The bubonic plague epidemic that began in 1346 led to the formation of universities in cities far from the major centers of learning (and hot spots of the Black Death) at that time. And the Anopheles mosquito and malaria aided General George Washington during the American Revolution. Sadly, when microbes have inflicted death and suffering, people have sometimes responded by invoking discrimination, scapegoating, and quarantine, often unfairly, against races or classes of people presumed to be the cause of the epidemic. Pathogens are not the only stars of this book. Many scientists and physicians who toiled to understand, treat, and prevent these plagues are also featured. Sherman tells engaging tales of the development of vaccines, anesthesia, antiseptics, and antibiotics. This arsenal has dramatically reduced the suffering and death caused by infectious diseases, but these plague protectors are imperfect, due to their side effects or attenuation and because microbes almost invariably develop resistance to antimicrobial drugs. The Power of Plagues provides a sobering reminder that plagues are not a thing of the past. Along with the persistence of tuberculosis, malaria, river blindness, and AIDS, emerging and remerging epidemics continue to confound global and national public health efforts. West Nile virus, Lyme disease, and Ebola and Zika viruses are just some of the newest rogues to plague humans. The argument that civilization has been shaped to a significant degree by the power of plagues is compelling, and The Power of Plagues makes the case in an engaging and informative way that will be satisfying to scientists and non-scientists alike.

Оглавление

Irwin W. Sherman. The Power of Plagues

Table of Contents

List of Tables

List of Illustrations

Guide

Pages

THE POWER OF PLAGUES

Preface to the Second Edition

1. The Nature of Plagues

Living Off Others

Plagues and Parasites

Predicting Plagues

A Measles Outbreak

The Evolution of Plagues

2. Plagues, the Price of Being Sedentary

Becoming Human, Becoming Parasitized

The Road to Plagues: More Humans, More Disease

The Effect of Agriculture

The Lethal Gifts of Agriculture

The Accident That Caused Societal Differences

3. Six Plagues of Antiquity

The Pharaohs’ Plague

The Plague of Athens

The Roman Fever

Plagues and the Rise of Christianity

The Antonine Plague

The Cyprian Plague

The Justinian Plague

4. An Ancient Plague, the Black Death

A Look Back

Public Health

Discrimination

Church

Medicine

Education

Economy and Social Order

Finding the Killer

Finding the Vector

The Disease of Plague

The Plague-Causing Bacterium, Yersinia pestis

Plague Today

Vaccines

Coda

5. A 21st Century Plague

A Look Back

HIV Discovered

The Genes of HIV

HIV Targets Immune Cells

HIV and AIDS

Failure To Control by Antibody or Vaccine

AZT, the First Antiretroviral Drug

Beyond AZT

“Catching” HIV

Control of AIDS

HIV and the African Connection

The Sooty Mangabey Connection: HIV-2

The Social Context of AIDS

6. Typhus, A Fever Plague

A Look Back

Typhus in People

Finding the Killer

A Lousy Business

Discrimination and Dissemination

Typhus and the “Immigrant Problem”

Typhus Today

Typhus Vaccine

Coda

7. Malaria, Another Fever Plague

A Look Back

The Disease Malaria

“Catching” Malaria

Malaria Today

Treatment

Prevention of Malaria

Genetic Resistance to Malaria: Sickle Cell Trait and Duffy Factor

The Elusive Malaria Vaccine

Coda

8 “King Cholera”

A Look Back

The Disease Cholera

Pandemic Cholera

Death by Dehydration

”Catching” Cholera

Controlling Cholera

Cholera, Sanitation, and Public Health

John Snow, the Father of Epidemiology

Cholera Today

Cholera and Nursing

Cholera and the “Immigrant Problem”

Coda

9. Smallpox, The Spotted Plague

A Look Back

The Disease of Smallpox

“Catching” Smallpox

Variolation

Vaccination

Vaccination and Its Social Context

Coda

10. Preventing Plagues: Immunization

The Immune System

Inflammation and innate immunity

Acquired immunity

Clonal selection theory

Autoimmunity

Diphtheria

Emil Behring and serum therapy

Paul Ehrlich

Toxin, antitoxin, and toxoid

Diphtheria today

Diphtheria, whooping cough, and the DTaP vaccine

Why Do Antibodies Work?

Attenuation and Immunization

Influenza

Measles

Mumps

Rubella

Whooping Cough

Chickenpox

Polio

John Enders

Jonas Salk

Albert Sabin

Aftermath

Cell-Mediated Acquired Immunity

Coda

11. The Plague Protectors: Antiseptics and Antibiotics

Barbers, Bloodletting, and Antisepsis

Surgery, Disease, and Anesthesia

Laughing gas

Ether

Chloroform

Disease, Dyes, and Drugs

Prontosil

Penicillin

Aftermath

Antimicrobial Resistance

How AMR is acquired

What can be done about AMR?

Coda

12. The Great Pox, Syphilis

A Look Back

Spirochete Discovered

The Disease Syphilis

“Catching” Syphilis

Syphilis and Its Social Context

Diagnosing Syphilis

Treating Syphilis

Syphilis and the Social Reformers

Distribution and Incidence of Syphilis

Vaccines against Syphilis

Coda

13. The People’s Plague: Tuberculosis

A Look Back

The Germ of TB

The Disease of TB

Today’s Diagnosis of TB

Heroin and TB

Controlling Consumption

Selman, Schatz, and Streptomycin

Drug Resistance

Drug Resistance Redux

Vaccination against TB

Incidence of TB

Coda

14. Leprosy, the Striking Hand of God

A Look Back

The Disease of Leprosy

Where Leprosy Is

Leprosy Today

“Catching” Leprosy

Coda

15. Six Plagues of Africa

Slavery and European Exploration

Endemic Diseases of Africa

Plagues Out of Africa

16. Emerging and Reemerging Plagues

Blame It on the Rodents

On the Wings of Birds

Anthrax

Robert Koch

Louis Pasteur

Madness and the Infectious Protein

Ebola

Zika Disease

Lyme Disease

The Conquest of Plagues

Appendix. Cells and Viruses

Notes

Chapter 1. The Nature of Plagues

Chapter 2. Plagues, the Price of Being Sedentary

Chapter 3. Six Plagues of Antiquity

Chapter 4. An Ancient Plague, the Black Death

Chapter 5. A 21st-Century Plague, AIDS

Chapter 6. Typhus, A Fever Plague

Chapter 7. Malaria, Another Fever Plague

Chapter 8. “King Cholera”

Chapter 9. Smallpox, the Spotted Plague

Chapter 10. Preventing Plagues: Immunization

Chapter 11. The Plague Protectors: Antiseptics and Antibiotics

Chapter 12. The Great Pox, Syphilis

Chapter 13. The People’s Plague: Tuberculosis

Chapter 14. Leprosy, The Striking Hand of God

Chapter 15. Six Plagues of Africa

Chapter 16. Emerging and Reemerging Plagues

Bibliography. General Works on Disease and History

Works Cited in the Text

Index. A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Q

R

S

T

U

V

W

X

Y

Z

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Second Edition

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Epidemiologists know that host population density is critical in determining whether a parasite can become established and persist. The threshold value for disease establishment can be obtained by finding the population density for which R0 = 1. In general, the size of the population needed to maintain an infection varies inversely with the transmission efficiency and directly with the death rate (virulence). Thus, virulent parasites, that is, those causing an increased number of deaths, require larger populations to be sustained, whereas parasites with reduced virulence may persist in smaller populations.

Measles, caused by a virus, provides an almost ideal pattern for studying the spread of a disease in a community. The virus is transmitted through the air as a fine mist released through coughing, sneezing, and talking. The virus-laden droplets reach the cells of the upper respiratory tract (nose and throat) and the eyes and then move on to the lower respiratory tract (lungs and bronchi). After infection, the virus multiplies for 2 to 4 days at these sites and then spreads to the lymph nodes, where another round of multiplication occurs. The released viruses invade white blood cells and are carried to all parts of the body using the bloodstream as a waterway. During this time the infected individual shows no signs of disease. But after an incubation period (8 to 12 days), there is fever, weakness, loss of appetite, coughing, a runny nose, and a tearing of the eyes. Virus replication is now in high gear. Up to this point the individual probably believes his or her suffering is a result of a cold or influenza, but when a telltale rash appears—first on the ears and forehead and then spreading over the face, neck, trunk, and to the feet—it is clearly neither influenza nor a common cold. Once a measles infection has begun, there is no treatment to halt the spread of the virus in the body.

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