The Power of Plagues
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Irwin W. Sherman. The Power of Plagues
Table of Contents
List of Tables
List of Illustrations
Guide
Pages
THE POWER OF PLAGUES
Preface to the Second Edition
1. The Nature of Plagues
Living Off Others
Plagues and Parasites
Predicting Plagues
A Measles Outbreak
The Evolution of Plagues
2. Plagues, the Price of Being Sedentary
Becoming Human, Becoming Parasitized
The Road to Plagues: More Humans, More Disease
The Effect of Agriculture
The Lethal Gifts of Agriculture
The Accident That Caused Societal Differences
3. Six Plagues of Antiquity
The Pharaohs’ Plague
The Plague of Athens
The Roman Fever
Plagues and the Rise of Christianity
The Antonine Plague
The Cyprian Plague
The Justinian Plague
4. An Ancient Plague, the Black Death
A Look Back
Public Health
Discrimination
Church
Medicine
Education
Economy and Social Order
Finding the Killer
Finding the Vector
The Disease of Plague
The Plague-Causing Bacterium, Yersinia pestis
Plague Today
Vaccines
Coda
5. A 21st Century Plague
A Look Back
HIV Discovered
The Genes of HIV
HIV Targets Immune Cells
HIV and AIDS
Failure To Control by Antibody or Vaccine
AZT, the First Antiretroviral Drug
Beyond AZT
“Catching” HIV
Control of AIDS
HIV and the African Connection
The Sooty Mangabey Connection: HIV-2
The Social Context of AIDS
6. Typhus, A Fever Plague
A Look Back
Typhus in People
Finding the Killer
A Lousy Business
Discrimination and Dissemination
Typhus and the “Immigrant Problem”
Typhus Today
Typhus Vaccine
Coda
7. Malaria, Another Fever Plague
A Look Back
The Disease Malaria
“Catching” Malaria
Malaria Today
Treatment
Prevention of Malaria
Genetic Resistance to Malaria: Sickle Cell Trait and Duffy Factor
The Elusive Malaria Vaccine
Coda
8 “King Cholera”
A Look Back
The Disease Cholera
Pandemic Cholera
Death by Dehydration
”Catching” Cholera
Controlling Cholera
Cholera, Sanitation, and Public Health
John Snow, the Father of Epidemiology
Cholera Today
Cholera and Nursing
Cholera and the “Immigrant Problem”
Coda
9. Smallpox, The Spotted Plague
A Look Back
The Disease of Smallpox
“Catching” Smallpox
Variolation
Vaccination
Vaccination and Its Social Context
Coda
10. Preventing Plagues: Immunization
The Immune System
Inflammation and innate immunity
Acquired immunity
Clonal selection theory
Autoimmunity
Diphtheria
Emil Behring and serum therapy
Paul Ehrlich
Toxin, antitoxin, and toxoid
Diphtheria today
Diphtheria, whooping cough, and the DTaP vaccine
Why Do Antibodies Work?
Attenuation and Immunization
Influenza
Measles
Mumps
Rubella
Whooping Cough
Chickenpox
Polio
John Enders
Jonas Salk
Albert Sabin
Aftermath
Cell-Mediated Acquired Immunity
Coda
11. The Plague Protectors: Antiseptics and Antibiotics
Barbers, Bloodletting, and Antisepsis
Surgery, Disease, and Anesthesia
Laughing gas
Ether
Chloroform
Disease, Dyes, and Drugs
Prontosil
Penicillin
Aftermath
Antimicrobial Resistance
How AMR is acquired
What can be done about AMR?
Coda
12. The Great Pox, Syphilis
A Look Back
Spirochete Discovered
The Disease Syphilis
“Catching” Syphilis
Syphilis and Its Social Context
Diagnosing Syphilis
Treating Syphilis
Syphilis and the Social Reformers
Distribution and Incidence of Syphilis
Vaccines against Syphilis
Coda
13. The People’s Plague: Tuberculosis
A Look Back
The Germ of TB
The Disease of TB
Today’s Diagnosis of TB
Heroin and TB
Controlling Consumption
Selman, Schatz, and Streptomycin
Drug Resistance
Drug Resistance Redux
Vaccination against TB
Incidence of TB
Coda
14. Leprosy, the Striking Hand of God
A Look Back
The Disease of Leprosy
Where Leprosy Is
Leprosy Today
“Catching” Leprosy
Coda
15. Six Plagues of Africa
Slavery and European Exploration
Endemic Diseases of Africa
Plagues Out of Africa
16. Emerging and Reemerging Plagues
Blame It on the Rodents
On the Wings of Birds
Anthrax
Robert Koch
Louis Pasteur
Madness and the Infectious Protein
Ebola
Zika Disease
Lyme Disease
The Conquest of Plagues
Appendix. Cells and Viruses
Notes
Chapter 1. The Nature of Plagues
Chapter 2. Plagues, the Price of Being Sedentary
Chapter 3. Six Plagues of Antiquity
Chapter 4. An Ancient Plague, the Black Death
Chapter 5. A 21st-Century Plague, AIDS
Chapter 6. Typhus, A Fever Plague
Chapter 7. Malaria, Another Fever Plague
Chapter 8. “King Cholera”
Chapter 9. Smallpox, the Spotted Plague
Chapter 10. Preventing Plagues: Immunization
Chapter 11. The Plague Protectors: Antiseptics and Antibiotics
Chapter 12. The Great Pox, Syphilis
Chapter 13. The People’s Plague: Tuberculosis
Chapter 14. Leprosy, The Striking Hand of God
Chapter 15. Six Plagues of Africa
Chapter 16. Emerging and Reemerging Plagues
Bibliography. General Works on Disease and History
Works Cited in the Text
Index. A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
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Second Edition
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Epidemiologists know that host population density is critical in determining whether a parasite can become established and persist. The threshold value for disease establishment can be obtained by finding the population density for which R0 = 1. In general, the size of the population needed to maintain an infection varies inversely with the transmission efficiency and directly with the death rate (virulence). Thus, virulent parasites, that is, those causing an increased number of deaths, require larger populations to be sustained, whereas parasites with reduced virulence may persist in smaller populations.
Measles, caused by a virus, provides an almost ideal pattern for studying the spread of a disease in a community. The virus is transmitted through the air as a fine mist released through coughing, sneezing, and talking. The virus-laden droplets reach the cells of the upper respiratory tract (nose and throat) and the eyes and then move on to the lower respiratory tract (lungs and bronchi). After infection, the virus multiplies for 2 to 4 days at these sites and then spreads to the lymph nodes, where another round of multiplication occurs. The released viruses invade white blood cells and are carried to all parts of the body using the bloodstream as a waterway. During this time the infected individual shows no signs of disease. But after an incubation period (8 to 12 days), there is fever, weakness, loss of appetite, coughing, a runny nose, and a tearing of the eyes. Virus replication is now in high gear. Up to this point the individual probably believes his or her suffering is a result of a cold or influenza, but when a telltale rash appears—first on the ears and forehead and then spreading over the face, neck, trunk, and to the feet—it is clearly neither influenza nor a common cold. Once a measles infection has begun, there is no treatment to halt the spread of the virus in the body.
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