Pathogenesis of cancer

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Группа авторов. Pathogenesis of cancer

INTRODUCTION

MALIGNANT DISEASES

ONCOGENESIS

MONONUCLEAR ONCOGENESIS PROGRAM

STEPS

PROTOTYPES

BASE

MECHANISM

FEATURES

RESULT

FUNDAMENTALS

CONCLUSIONS

Отрывок из книги

Carcinogenesis or oncogenesis is a multi-stage mechanism of the emergence, growth and development of a malignant process. According to the modern theory of carcinogenesis, the occurrence of a malignant tumor is the result of the sequential accumulation of mutations in the somatic cells of the body that are not inherited. When the number of mutations becomes critical, the formation of a primary malignant stem cell occurs. The weak link of this theory is the absence of a cancer cell precursor cell. In a morphological study, it looks like this: a healthy normal cell, next to it a malignant cell, there is no transitional variant or precursor cell to a cancer cell.

General signs of hemoblastoses and solid tumors.

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– the mechanism of a malignant stem cell “birth” is the genotype and epigenetic changes of a pluripotent or unipotent stem cell of lymphopoiesis following the carcinogenic impact;

– the malignant process starts from the “birth” of one malignant stem cell, which then forms a clone of malignant cells;

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