Routes to Essential Medicines

Routes to Essential Medicines
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This comprehensive workbook helps readers become familiar with the structures and synthetic challenges associated with nearly 300 essential medicines and gain the skills needed for pharmaceutical development. Highlights nearly three hundred medicines on the latest World Health Organization (WHO) Model List of Essential Medicines and their manufacturing routes Features exercises that equip students with the skills necessary to solve similar real-world problems Includes a retrosynthetic analysis for each commodity chemical and supplies an extensive list of key journal and information sites and a library of reagents, solvents, and conditions for many common organic reactions

Оглавление

Peter J. Harrington. Routes to Essential Medicines

Table of Contents

Guide

Pages

Routes to Essential Medicines. A Workbook for Organic Synthesis

About the Companion Website

Introduction

Workbook Organization

A. Abacavir

Extended Discussion

Acetazolamide

Extended Discussion

Acetylcysteine

Acetylsalicylic Acid

Acyclovir

Extended Discussion

Albendazole

Extended Discussion

Allopurinol

Extended Discussion

Amidotriazoate

Extended Discussion

Amikacin

Extended Discussion

Amiloride

Extended Discussion

4‐Aminosalicylic Acid

Extended Discussion

Amiodarone

Extended Discussion

Amitriptyline

Extended Discussion

Amlodipine

Extended Discussion

Amodiaquine

Extended Discussion

Amoxicillin

Extended Discussion

Ampicillin

Extended Discussion

Anastrozole

Extended Discussion

Artemether

Extended Discussion

Artesunate

Extended Discussion

Ascorbic Acid

Extended Discussion

Atazanavir

Extended Discussion

Atracurium Besylate

Extended Discussion

Atropine

Extended Discussion

Azathioprine

Extended Discussion

Azithromycin

Extended Discussion

Aztreonam

Extended Discussion

B. Beclomethasone Dipropionate

Extended Discussion

Bedaquiline

Extended Discussion

Bendamustine

Extended Discussion

Benznidazole

Extended Discussion

Benzoyl Peroxide

Benzyl Benzoate

Extended Discussion

Betamethasone

Extended Discussion

Bicalutamide

Extended Discussion

Biperiden

Extended Discussion

Bisoprolol

Extended Discussion

Budesonide

Extended Discussion

Bupivacaine

Extended Discussion

C. Caffeine

Extended Discussion

Calcium Folinate/Folinic Acid

Extended Discussion

Capecitabine

Carbamazepine

Extended Discussion

Cefalexin

Extended Discussion

Cefazolin

Extended Discussion

Cefepime

Extended Discussion

Cefixime

Extended Discussion

Cefotaxime

Extended Discussion

Ceftaroline

Extended Discussion

Ceftazidime

Extended Discussion

Ceftriaxone

Extended Discussion

Chlorambucil

Extended Discussion

Chloramphenicol

Extended Discussion

Chlorhexidine

Extended Discussion

Chloroquine

Extended Discussion

Chloroxylenol

Chlorpromazine

Extended Discussion

Ciprofloxacin

Extended Discussion

Cisplatin, Carboplatin, Oxaliplatin

Extended Discussion

Clarithromycin

Extended Discussion

Clindamycin

Extended Discussion

Clofazimine

Extended Discussion

Clomifene

Extended Discussion

Clomipramine

Extended Discussion

Clopidogrel

Extended Discussion

Cloxacillin

Extended Discussion

Clotrimazole

Extended Discussion

Clozapine

Extended Discussion

Codeine

Extended Discussion

Colecalciferol

Extended Discussion

Cyclizine

Cyclophosphamide

Extended Discussion

Cycloserine

Extended Discussion

Cytarabine

Extended Discussion

D. Dacarbazine

Extended Discussion

Daclatasvir

Extended Discussion

Dapsone

Extended Discussion

Darunavir

Extended Discussion

Dasabuvir

Extended Discussion

Dasatinib

Extended Discussion

Delamanid

Extended Discussion

Desmopressin

Extended Discussion

Dexamethasone

Extended Discussion

Diazepam

Extended Discussion

Diethylcarbamazine

Extended Discussion

Dihydroartemisinin

Extended Discussion

Diloxanide Furoate

Dimercaprol

Docetaxel

Extended Discussion

Docusate Sodium

Dolutegravir

Extended Discussion

Dopamine

Extended Discussion

Doxycycline

Extended Discussion

E. Efavirenz

Extended Discussion

Eflornithine

Extended Discussion

Emtricitabine

Extended Discussion

Enalapril

Extended Discussion

Entecavir

Extended Discussion

Ephedrine

Extended Discussion

Epinephrine

Extended Discussion

Ergocalciferol

Ergometrine

Estradiol Cypionate

Extended Discussion

Ethambutol

Extended Discussion

Ethinylestradiol

Extended Discussion

Ethionamide

Extended Discussion

Ethosuximide

Etonogestrel

Extended Discussion

Etoposide

Extended Discussion

F. Fentanyl

Extended Discussion

Fluconazole

Extended Discussion

Flucytosine

Extended Discussion

Fludarabine Phosphate

Extended Discussion

Fludrocortisone Acetate

Fluorouracil

Extended Discussion

Fluoxetine

Extended Discussion

Fluphenazine

Extended Discussion

Folic Acid

Extended Discussion

Fomepizole

Extended Discussion

Formoterol

Extended Discussion

Fosfomycin

Extended Discussion

Furosemide

Extended Discussion

G. Gemcitabine

Extended Discussion

Gliclazide

Extended Discussion

Glutaral

Glyceryl Trinitrate

Extended Discussion

H. Haloperidol

Extended Discussion

Halothane

Extended Discussion

Hydralazine

Extended Discussion

Hydrochlorothiazide

Extended Discussion

Hydrocortisone

Extended Discussion

Hydroxycarbamide

Hydroxychloroquine

Extended Discussion

Hyoscine Butylbromide

I. Ibuprofen

Extended Discussion

Ifosfamide

Extended Discussion

Imatinib

Extended Discussion

Iohexol

Extended Discussion

Ipratropium Bromide

Extended Discussion

Irinotecan

Extended Discussion

Isoflurane

Extended Discussion

Isoniazid

Extended Discussion

Isosorbide Dinitrate

Extended Discussion

Itraconazole

Extended Discussion

Ivermectin

Extended Discussion

K. Ketamine

Extended Discussion

L. Lactulose

Extended Discussion

Lamivudine

Extended Discussion

Lamotrigine

Extended Discussion

Latanoprost

Extended Discussion

Ledipasvir

Extended Discussion

Leuprorelin

Extended Discussion

Levamisole

Extended Discussion

Levofloxacin

Extended Discussion

Levonorgestrel

Extended Discussion

Levothyroxine

Extended Discussion

Lidocaine

Extended Discussion

Linezolid

Extended Discussion

Loperamide

Extended Discussion

Lopinavir

Extended Discussion

Loratidine

Extended Discussion

Lorazepam

Extended Discussion

Losartan Potassium

Extended Discussion

Lumefantrine

M. Mannitol

Mebendazole

Extended Discussion

Medroxyprogesterone Acetate

Extended Discussion

Mefloquine

Extended Discussion

Meglumine Iotroxate

Melarsoprol

Extended Discussion

Mercaptopurine

Extended Discussion

Meropenem

Extended Discussion

Mesna

Extended Discussion

Metformin

Methadone

Extended Discussion

Methotrexate

Extended Discussion

Methyldopa

Extended Discussion

Methylprednisolone

Extended Discussion

Methylthioninium Chloride

Extended Discussion

Metoclopramide

Extended Discussion

Metronidazole

Extended Discussion

Miconazole

Extended Discussion

Midazolam

Extended Discussion

Mifepristone

Extended Discussion

Miltefosine

Extended Discussion

Misoprostol

Extended Discussion

Moxifloxacin

Extended Discussion

N. Naloxone

Extended Discussion

Neostigmine Methylsulfate

Extended Discussion

Nevirapine

Extended Discussion

Niclosamide

Extended Discussion

Nicotinamide

Nifedipine

Extended Discussion

Nifurtimox

Extended Discussion

Nilotinib

Nitrofurantoin

Extended Discussion

Norethisterone and Norethisterone Enanate

Extended Discussion

O. Ofloxacin

Extended Discussion

Ombitasvir

Omeprazole

Ondansetron

Extended Discussion

Oseltamivir

Extended Discussion

Oxamniquine

Extended Discussion

Oxytocin

Extended Discussion

P. Paclitaxel

Paracetamol

Extended Discussion

Paritaprevir

Extended Discussion

Penicillamine

Extended Discussion

Pentamidine

Extended Discussion

Permethrin

Extended Discussion

Phenobarbital

Extended Discussion

Phenytoin

Extended Discussion

Piperacillin

Extended Discussion

Piperaquine

Extended Discussion

Praziquantel

Extended Discussion

Prednisolone

Extended Discussion

Primaquine

Extended Discussion

Procarbazine

Extended Discussion

Progesterone

Extended Discussion

Proguanil

Extended Discussion

Propofol

Extended Discussion

Propranolol

Extended Discussion

Propylthiouracil

Extended Discussion

Prostaglandin E1

Extended Discussion

Prostaglandin E2

Extended Discussion

Pyrantel

Extended Discussion

Pyrazinamide

Extended Discussion

Pyridoxine

Extended Discussion

Pyridostigmine Bromide

Extended Discussion

Pyrimethamine

Extended Discussion

Pyronaridine

Extended Discussion

R. Raltegravir

Extended Discussion

Ranitidine

Extended Discussion

Retinoic Acid (All‐trans)

Retinol (Vitamin A1)

Extended Discussion

Ribavirin

Extended Discussion

Rifabutin

Extended Discussion

Rifampicin

Rifapentine

Extended Discussion

Risperidone

Extended Discussion

Ritonavir

Extended Discussion

S. Salbutamol

Extended Discussion

Simeprevir

Extended Discussion

Simvastatin

Extended Discussion

Sodium Calcium Edetate

Extended Discussion

Sofosbuvir

Extended Discussion

Spironolactone

Extended Discussion

Succimer

Extended Discussion

Sulfadiazine and Silver Sulfadiazine

Extended Discussion

Sulfadoxine

Extended Discussion

Sulfamethoxazole

Extended Discussion

Sulfasalazine

Extended Discussion

Suramin

Suxamethonium Chloride

Extended Discussion

T. Tamoxifen

Discussion

Extended Discussion

Tazobactam

Discussion

Extended Discussion

Tenofovir Disoproxil

Extended Discussion

Terbinafine

Extended Discussion

Testosterone

Extended Discussion

Tetracaine

Extended Discussion

Tetracycline

Thiamine

Extended Discussion

Tigecycline

Extended Discussion

Timolol

Extended Discussion

Tranexamic Acid

Extended Discussion

Triclabendazole

Extended Discussion

Trimethoprim

Extended Discussion

Tropicamide

Extended Discussion

U. Ulipristal Acetate

Extended Discussion

V. Valganciclovir

Extended Discussion

Valproic Acid

Extended Discussion

Vecuronium Bromide

Extended Discussion

Velpatasvir

Extended Discussion

Verapamil

Extended Discussion

Vincristine

Vinorelbine

Extended Discussion

Voriconazole

Extended Discussion

W. Warfarin

Extended Discussion

X. Xylometazoline

Extended Discussion

Z. Zidovudine

Extended Discussion

Zoledronic Acid

A Demonstration: Amiodarone

Route Summary

References

Pros and Cons for Routes A and B to 2‐Butylbenzofuran

Index. a

b

c

d

e

f

g

i

j

k

l

m

n

o

p

r

s

t

u

v

w

x

z

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Peter J. Harrington

.....

Draw the structures of the retrosynthetic analysis of an alternative route from 3‐chloroaniline to 7‐chloro‐4‐hydroxyquinoline utilizing a Conrad–Limpach Reaction. Include the structures of the retrosynthetic analysis of any organic starting material(s) from petrochemical or biochemical raw materials. List pros and cons for the two routes and select one route as the preferred route.

Anti‐Infective Medicines/Antibacterials/Beta‐Lactam Medicines

.....

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