Modern Epidemics

Modern Epidemics
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COVID-19 has made us all aware of the fact that we live in a world full of invisible enemies. Normally, we don’t even realize they’re there, but from time to time one of these microscopic creatures becomes powerful enough to turn everything upside down. What are these invisible enemies, and how can we prepare ourselves for the pandemics of the future? A specialist in the cellular biology of diseases, Salvador Macip explains, in a language everyone can understand, what it means to share the planet with millions of microbes – some wonderful allies, others terrible foes. He provides a concise account of epidemics that changed history, and focuses on the great modern plagues that are still causing millions of deaths every year, from influenza, TB and malaria to COVID-19. Macip also examines the methods we have used – from vaccines to improved sanitation and social distancing – to try to control these invisible enemies. This authoritative overview of modern epidemics and the pathogens that cause them will be essential reading for anyone who wants to understand our world today, a world in which some of the greatest threats to the human species come from the invisible microbes with which we share this planet.

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Salvador Macip. Modern Epidemics

CONTENTS

Guide

Pages

MODERN EPIDEMICS. From the Spanish Flu to COVID-19

Dedication

Acknowledgements

Introduction. An ever-present danger

Let’s do our homework

A tool for understanding the present and preparing for the future

1 Travel Companions

They were here first

Space: the last frontier

Peaceful passengers

Nomenclature

Secondary effects

The dark side

A bit of terminology

Which disease spreads fastest?

Typhoid Mary

Bacteria

Viruses: the smallest life form?

Fungi: microscopic mushrooms

2 The Story of a Never-Ending Struggle

The invisible hand behind things

Just one victim, tremendous consequences

A bacterium to blame for a new religion

Rats, fleas, and bacteria

Delayed benefits

The ‘Spanish’ flu

We don’t learn from our errors

The resuscitated virus

Smallpox, a disease of the past

Poliomyelitis: next on the list?

Titbits: famous people with polio

Cost in lives, cost in money

3 Our Arsenal

Simple but vital

The immune system

The strong sex

The next step forward: vaccines

Types of vaccine

Cancer vaccines

The papilloma vaccine, a controversial solution

The danger of listening to the wrong people

More conspiracies

The real precedent

Dangerous decisions

Future challenges

Four questions for Adolfo García-Sastre, director of the Global Health and Emerging Pathogens Institute at the Mount Sinai Hospital in New York

Antibiotics: the offensive begins

A classical story

Powerful poisons or a sophisticated messaging system?

Miracles with an expiry date

The microbes of the future

Doctors fight resistance

MRSA starts spreading

Resting on our laurels

Let’s see who wins …

The antibiotics of the future

Antivirals

Myth and reality: low temperatures make us catch colds

Who pays the bills?

Revolutionary ideas

Shock troops

Control and prevention

4 The Danger of Knowing Too Much

The paradox: the more we research, the greater the danger

Deadly leak

Has anyone seen my virus?

Dangerous information

Anthrax

Types of biological agents susceptible to being used as weapons (from more to less toxic, according to CDC in the United States)

A controversial name

Bioterrorists in the USA

The wrong man

The return of smallpox?

The silicon mystery

5 Forgotten Diseases and New Diseases

The new infectious diseases

Meningitis

Cholera

Cinematographic viruses

West Nile virus

Ebola

Types of microbiology laboratories

Marburg: the other serious haemorrhagic fever

The cure is worse than the disease

The ‘forgotten’ diseases

‘Forgotten diseases’ covered by the WHO programme

Chagas disease

Dengue

An additional danger of global warming

Hand, foot and mouth disease

6 Coronaviruses and Future Pandemics. Coronaviruses: the new plague?

SARS: the coronaviruses enter the scene

Panic hotel

MERS, or camel sickness

COVID-19 changes everything

How to stop the virus

The vaccine race

The future of the pandemic

First-class passports

What lies ahead for SARS-CoV-2

Lessons from COVID-19: how to manage a crisis

And the next pandemic?

The virus that will come in from the heat

Where is the ‘supervirus’?

Predicting pandemics with your computer

Health and economy: an inevitable relationship

How can we prevent the spread?

Getting in on the ground floor

7 Influenza

Protected forever?

The virus’s thousand faces

ID cards

The killer cold

A winter malady

Aggressive outbreaks

A useful treatment

One vaccine or many vaccines?

The future of humanity depends on an egg

The danger of bird flu

The name game

The 2009 influenza pandemic

The genealogical tree

Was it really swine flu?

Background: the 1976 flu

A lab virus?

No one escapes it

Drugs and the race against time

Epidemic or pandemic?

Flu pandemic phases of alert (according to the WHO)

A change of hemispheres

Does it make sense to close schools?

Prepare for the worst

Who should be given the vaccine?

The consequences of the pandemic

8 AIDS

Myth and reality: how is AIDS spread?

Another multifaceted virus

The African sickness

Rumours

The myth of ‘patient zero’

A scientists’ squabble

So, who discovered HIV?

The Nobel of discord

The silent infection

Closing borders

Necessary swift diagnosis

A miraculous treatment … that doesn’t cure

Strange bedfellows

More options

Side effects

The virus becomes more dangerous

The false ‘superbug’

Treatments for the future

And the famous vaccine?

Natural selection (with a bit of help from viruses)

Defence is the best attack

Radical prevention

Myth and reality: someone who is being treated for AIDS can’t infect another person through sexual contact

An economical prevention?

Where does the money come from?

A gift with strings attached

Denialists: as dangerous as the virus

Myth and reality: vitamins are effective in combating AIDS

They are everywhere

9 Tuberculosis

Koch’s bacillus: an armoured microbe

Koch’s postulates

A problem that comes back

The threat of resistant tuberculosis

Primitive treatments

New treatments, old treatments

Is there some solution?

Another disease with no vaccine

The tuberculosis that comes from cows

Cleaning up milk

10 Malaria

All because of a mosquito

Mosquitoes are gourmets too

To catch a mosquito

Goodwill is not enough

Myth and reality

A medicinal cocktail

The treatment and how to get it to people who need it

Has the time of resistances come?

Phases of a clinical study

The controversial SPf66 vaccine

Myth and reality

The army is also researching

Against the insects: mosquito nets and genetic engineering

Global action

A tropical disease only?

Bill Gates’s unfunny joke

Epilogue

Glossary

Index

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Q

R

S

T

U

V

W

X

Y

Z

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Отрывок из книги

Salvador Macip

Translated from Catalan by Julie Wark

.....

Bacteria are microbes consisting of a single cell. After the sixteenth century, there were theories postulating that diseases were transmitted by a kind of ‘seed’ that went from one person to another but, without the necessary instruments, it was impossible to confirm this idea. It wasn’t until the seventeenth century, when the Dutchman Antonie van Leeuwenhoek invented the microscope, that it was possible to discover these ‘germs’, as they were originally called. In one of his first observations, he described something like abundant ‘very little animalcules’, which were everywhere. He named them animalculae and proposed that they were responsible for infections. It was only possible to demonstrate this in the nineteenth century and, in 1838, Leeuwenhoek’s animalculae were officially named bacteria.

There are many classes of bacteria and they can have very different forms. The most typical are round and they’re called cocci, while the elongated ones are known as bacilli. They are found everywhere, and in abundance. For example, there are 40 million bacteria in every gram of earth, and 1 million for each millilitre of water. If we counted all the bacteria on the planet, we would get a figure with thirty zeros. It’s therefore believed that most of the types that exist haven’t yet been discovered or identified.

.....

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