General system theory of aging. Special role of the immune system

Оглавление

V. I. Dontsov. General system theory of aging. Special role of the immune system

Introduction

Main Points

Chapter 1. Methodology and principles of studying the aging phenomenon

1.1. The main methodological errors, myths, and cliches in the general analysis of the problem of aging

1.2. History of views on the aging process

1.3. Methodology of knowledge: three stages, three paradigms

1.4. Features of the system approach as a modern universal scientific method of problem analysis

1.4.1. Using a systematic approach to analyze оf aging process

1.4.2. General methodology about the cause of phenomena

1.4.3. Aging Hierarchy

1.5. Essential modeling – the basis of understanding the phenomenon of aging

Chapter 2. Theoretical approaches to the study of aging phenomenon

2.1. Essential definition and cause of aging

2.2. Chaos and order processes, entropy and energy

2.3. The basic formula and the basic law of aging

2.4. Basic global mechanisms: types of aging

2.4.1. The main common mechanisms are types of aging

2.4.2. Stochastic dependent death non-elements of the system

2.4.3. Stochastic dependent cumulative mechanism of aging

2.4.4. Regulatory aging

2.4.5. The relationship of the main mechanisms of aging

Chapter 3. Modeling the phenomenon and mechanisms of aging

3.1. Mechanical model of system aging

3.1.1. An example of a mechanical model of aging systems

3.1.2. From mechanical to a biological system

3.2. Modeling of global aging mechanisms

3.2.1. Simulation of stochastic-dependent system “pollution”

3.2.2. Simulation of stochastic-dependent death of non-recovering system elements

3.2.3. Regulatory aging modeling

3.2.4. Obtaining an analogue of the Gompertz-Makema formula from the regulatory model of aging

3.2.5. Modeling the interaction of the three fundamental mechanisms of aging

3.3. Unified Systems Theory of Aging

3.4. A systematic approach to the diagnosis of aging

3.4.1. Fundamentals of the diagnosis of aging

3.4.2. Estimation of the rate of aging according to the graphs of the intensity of mortality

3.4.3. Does it exist a correlation of Strehler-Mildwan?

3.4.4. Mortality as an indicator of aging: opportunities and limitations

3.4.5. Individual diagnosis of aging – biological age

3.4.6. Artificial intelligence capabilities for analyzing human biomarkers

3.4.7. Diagnosis of syndromes and manifestations of aging

3.5. Systematic approach and ways of influencing aging

3.5.1. Fundamental causes of aging and general routes of exposure

3.5.2. Aging syndromes, their diagnosis and ways of correction

3.5.3. Types of metabolic disorders

3.5.4. Geroprotectors – special anti-age medicine

3.5.5. Elements of tactics in the diagnosis of aging

3.6. Whether the treatment of age-related diseases anti-aging therapy

Chapter 4. The regulatory theory of aging as the main mechanism for the aging of biological systems

4.1. Some examples from evolutionary biology

4.2. Age-related cell degeneration as the basis of aging

4.3. Ways to restore regulatory programs

4.4. Practical approaches to life extension

Chapter 5. Self-organization of growing cellular systems and the integrative role of the immune system

5.1. Self-organization of cellular systems – the basis of the formation of the body

5.1.1. Regulation of proliferation of single-type cells (Chalons)

5.1.2. “Cell hypercycle” – the basis of self-regulation and self-sustaining multicellular organism

5.1.3. The evolution of the cell hypercycle

5.1.4. Functioning of the cell hypercycle

5.2. T lymphocytes – growth regulators of somatic cells

5.2.1. Data on the regulation of lymphocyte growth of somatic cells

5.2.2. Specialized cellular system for regulating the growth of somatic tissues

5.2.3 Properties of lymphocyte growth regulators cells

5.2.4. The new concept of the emergence of immunity

Chapter 6. A New Immuno-Regulatory Theory of Aging

6.1. Changes in the immune system during aging

6.2. New immuno-regulatory theory of aging

6.3. Prospects for immuno-correction of aging

6.3.1. Study of lymphocyte regulators of the cell growth experiment

6.3.2. Influence of an immunomodulator Transfer factor on aging

Conclusion

Appendix

References

Отрывок из книги

V.I. Dontsov. General system theory of aging. Special role of the immune system. 2019. – 320 p. Electronic edition. Figures – 57. Schemes – 4. Tables – 4. Formulas – 9.

Translation from Russian by the service of Springer Edit.

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Ways to restore regulatory programs – the most promising direction for the impact on aging.

The problem of recovery and correction of regulatory programs of the brain is central to age biology, since many body functions (sexual, immune, metabolic rate, total hormones and the balance of different types of hormones, nervous trophism, growth program, etc.) undergo drastic changes throughout life precisely because of the programmed changes in the regulatory centers, primarily at the level of the hypothalamus.

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