Читать книгу Anti-Aging Therapeutics Volume XIII - A4M American Academy - Страница 10

•Treatment alters standard diagnostic accuracy: A 2004 newsletter from the Prostate Cancer Research Institute reported that hormone therapy may change the way the pathologist interprets a cancer. Androgen deprivation therapy, (ADT) and similar medicines such as Proscar (finasteride), Avodart (dutasteride) and certain hair maintenance formulations, make it more difficult to grade the tumor with microscopic analysis. Dr. Pam Unger, a PCa pathology specialist at Mount Sinai Hospital in New York, mentioned in a personal communication that radiation changes also caused difficulties in reading the microscopic slides. Furthermore, pathologists generally don’t look for blood vessels, and thus, do not routinely evaluate the vascular pattern in the specimens they interpret.

•Blood flow, measured by Doppler sonogram, is not disrupted by treatments: The diagnostic accuracy of 3-D Doppler, based on blood flow analysis, is not altered by the treatments noted above. Men who have been on ADT should have a Doppler sonogram study to confirm the absence of residual disease. If there are areas of abnormal blood vessels, biopsy may be considered. Many patients who have been treated for cancer accept the presence of abnormal blood flows as proof of recurrence and choose treatments accordingly without further biopsies. Most patients use the amount of decrease in number of the visible blood vessels to represent the degree of success.