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Bhandari M, Jeray KJ, Petrisor BA, et al; FLOW Investigators. A trial of wound irrigation in the initial management of open fracture wounds. N Engl J Med 2015;373(27):2629–2641

D’Alleyrand JC, Manson TT, Dancy L, et al. Is time to flap coverage of open tibial fractures an independent predictor of flap-related complications? J Orthop Trauma 2014;28(5):288–293

Gosselin RA, Roberts I, Gillespie WJ. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev 2004(1):CD003764

Patzakis MJ, Bains RS, Lee J, et al. Prospective, randomized, double-blind study comparing single-agent antibiotic therapy, ciprofloxacin, to combination antibiotic therapy in open fracture wounds. J Orthop Trauma 2000;14(8):529–533

Patzakis MJ, Harvey JP Jr, Ivler D. The role of antibiotics in the management of open fractures. J Bone Joint Surg Am 1974;56(3):532–541

Pollak AN, Jones AL, Castillo RC, Bosse MJ, MacKenzie EJ, Group LS; LEAP Study Group. The relationship between time to surgical debridement and incidence of infection after open high-energy lower extremity trauma. J Bone Joint Surg Am 2010;92(1):7–15

Weber D, Dulai SK, Bergman J, Buckley R, Beaupre LA. Time to initial operative treatment following open fracture does not impact development of deep infection: a prospective cohort study of 736 subjects. J Orthop Trauma 2014;28(11):613–619

Synopsis of Orthopaedic Trauma Management

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