Читать книгу Enzyme-Based Organic Synthesis - Cheanyeh Cheng - Страница 21

Merck and Codexis have developed a second‐generation green synthesis of sitagliptin, the active ingredient in Januvia, a treatment for type 2 diabetes. This collaboration has led to an enzymatic process with transaminase that reduces waste, improves yield and safety, and eliminates the need for a metal catalyst. Early research suggests that the new biocatalysts will be useful in manufacturing other drugs as well.