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There are many variations on how apoptosis is regulated. As summarized in Figure 3.8, the events of apoptosis leading to cell death can be induced via one of two major pathways. Since the way this occurs during oogenesis is still a mystery, we will detail each of these. Continued research will reveal the importance of each pathway in egg cell death.

The intrinsic pathway, which occurs from within the cell, involves the release of cytochrome C from mitochondria which then activates the caspase cascade. In contrast the extrinsic pathway begins with the activation of death receptors on the cell surface, which in turn initiate signal transduction events leading to caspase activation and resultant cell death.

Figure 3.8. The intrinsic pathway and extrinsic pathway of apoptosis.