Читать книгу The Principles and Practice of Antiaging Medicine for the Clinical Physician - Dr. Vincent C. Giampapa - Страница 19

According to Dr. Stanley Burzynski, adult cells in the body have an established methylation pattern in their DNA that is essential to the aging program. But Dr. Burzynski also states that in the very first days of life this methylation pattern is erased. Most genes in our DNA are active during the initial embryonal development. Then they begin to become blocked through methylation as their expression is no longer needed. Many genes are silenced in this manner after birth, including the one for hemoglobin F (Fetal Hemoglobin). This trend accelerates especially after age 25 with increasing numbers of genes silenced as we grow older. If for any reason the silencing affects tumor suppressor genes, the aging person may develop cancer. Continuous silencing of genes in the aging bodies is a major factor leading to progressive aging and ultimately death. Dr. Burzynski has isolated a number of substances that can reactivate these tumor suppressor genes in cancer patients as well as reactivate other genes that are involved in symptomatic aspects of aging. He has termed these molecular switches antineoplastons. While activating tumor “suppressor genes to help alleviate the potential cancer, these antineoplastons “also “turn on” other genes, which can provide aging patients with a number of benefits. Therefore, Dr. Burzynski believes it is realistic to contemplate that we may be able to stop and reverse the pattern of methylation that occurs in normal aging by using properly designed molecules to act as “switches” that deactivate certain genes and activate more youthful genes.