Читать книгу Practical Cardiovascular Medicine - Elias B. Hanna - Страница 91
Physiology of hs-troponin
Оглавление1 184. Turer AT, Addo TA, Martin JL, et al. Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study. J Am Coll Cardiol 2011; 57(24):2398–2405.
2 185 Sabatine M.S., Morrow D.A., de Lemos J.A., et al. Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35. Eur Heart J 30:162–169.
3 186 de Lemos JA, Drazner MH, Omland T, et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA 2010; 304 (22):25032512.
4 187. Januzzi JL Jr, Suchindran S, Coles A, et al. High-sensitivity troponin I and coronary computed tomography in symptomatic outpatients with suspected coronary artery disease: insights from the PROMISE trial. J Am Coll Cardiol Img 2018;Epub ahead of prin. In this study of healthy individuals with no known CAD or typical symptoms (mean age 57), highest hs/troponin quartile was only >2.5 ng/L, and the highest quartile had 16% risk of significant CAD (low, but higher than lower quartiles (<5%, and 10%)). Risk of MI/death was low in all at 1 yr (0.4-1.2%),
5 188. Januzzi JL, Jr, Suchindran S, Hoffmann U, et al. Single-molecule hsTnI and short-term risk in stable patients with chest pain. J Am Coll Cardiol 2019; 73:251–260 (from PROMISE trial).
6 189. Sandoval Y, Bielinski SJ, Daniels LB, et al. Atherosclerotic Cardiovascular Disease Risk Stratification Based on Measurements of Troponin and Coronary Artery Calcium. J Am Coll Cardiol. 2020;76(4):357-370. Either calcium score of 0 or undetectable hs-troponin predicts a very low cardiac risk at 10 years. 38% of patients had discordant result and the 2 tests are complementary: the lowest risk is in patients with a calcium score of 0+undetectable hs-troponin.
7 190. Neilan TG,Januzzi JL, Lee-Lewandrowski E, et al. myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon. Circulation 2006; 114:2325–2333.
8 191. Mousavi N, Czarnecki A, Kumar K, et al. Relation of biomarkers and cardiac magnetic resonance imaging after marathon running. Am J Cardiol. 2009; 103(10):1467–1472.