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MODELS OF DISEASE PROGRESSION

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The patterns of disease progression have been extensively studied, aiming at evaluating how loss of attachment occurs over time. In 1982, Goodson et al68 described the progression of attachment level in 22 untreated patients performing measurements every month for 1 year. Results from this investigation demonstrated that the majority of the sites experienced no significant changes (82.8%), followed by 11.5% of the sites that became significantly shallower and 5.7% of sites that became significantly deeper. Within the group that suffered increase in probing depths, approximately half experienced progressive deepening and the other half presented with periods of exacerbation and spontaneous remission/recovery.68 In 1984, Socransky et al69 reviewed the available evidence and described three models of disease progression: continuous, random burst, and asynchronous multiple burst.68 In 1991, Jeffcoat and Reddy70 revisited this topic following patients with periodontitis for 6 months. In this investigation, three models were described as (1) linear or continuous (76% of sites), (2) burst (12% of sites), and (3) exacerbations and remission (12% of sites).70

Periodontics

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