Читать книгу Poisonous Plants and Phytochemicals in Drug Discovery - Группа авторов - Страница 42

These are related to biological characterization, but with the addition of relevance in therapeutic, pharmacokinetic, and pharmacodynamics activities. Although endophytes usually cause diseases to the host plants, they sometimes have beneficial effects to the plants as well as the animal kingdom that consume the attacked plants. Endophytic fungi has been known to have damaging properties on the leaves of c. Papaya for example but some toxic compounds isolated from these endophytes possess very good cytotoxic properties which can be used to develop drug compounds to control, manage and possibly cure cancers in its various specific stages. In the same understanding, these toxins can be instrumental in the pharmaceutical industry focusing on what they do as a means of their interaction with biological targets. Some can act better on fungi, others on bacteria, viruses and protozoa. Their interactions could span from cytotoxicity, metabolic modulation, imunal modulation, cell growth arrest or enhancement, transportation efficiency and excretion among other pharmacokinetic and physiological proccesses. All phytotoxins that have similar properties as described in the sections above can be categorised based on their pharmacological relevance and studied together.