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1 Chapter 1Figure 1.1 Transcriptional regulation of hepatocellular bile formation. Expr...Figure 1.2 Enterohepatic circulation of bile acids (BAs). After hepatic synt...Figure 1.3 Stem/progenitor cell niches in the human biliary tree. Canals of ...

2 Chapter 2Figure 2.1 Interaction of factors required for generation of autoimmune dise...Figure 2.2 Adaptive immune responses generate multiple mechanisms of cytotox...

3 Chapter 3Figure 3.1 LocusZoom plot of the PBC risk locus 16p13.13, illustrating that,...

4 Chapter 4Figure 4.1 Diluted patient serum is incubated with triple rodent tissue sect...Figure 4.2 ELISA (enzyme‐linked immunosorbent assay) as an example of a soli...Figure 4.3 Immune serology in autoimmune hepatitis: ANA, anti‐nuclear antibo...Figure 4.4 Immune serology in primary biliary cholangitis: AMA, anti‐mitocho...Figure 4.5 Diagnostic algorithm for autoimmune liver serology based on indir...

5 Chapter 5Figure 5.1 Models of microbial induction of autoimmune responses to pyruvate...Figure 5.2 Model for loss of tolerance to PDC‐E2 and PBC pathogenesis. (a) I...Figure 5.3 Primary biliary epithelial cells (BEC) develop the mitochondrial ...Figure 5.4 Immunochemistry studies show betaretrovirus proteins in the same ...

6 Chapter 6Figure 6.1 A and B. Panel A ‐ Histologic depiction of marked chronic portal ...Figure 6.2 Suggested treatment algorithm for management of autoimmune hepati...

7 Chapter 7Figure 7.1 Photomicrograph of stage 2 PBC.(a) Mononuclear inflammatory cell...Figure 7.2 Probability of remaining free of extensive fibrosis or cirrhosis ...Figure 7.3 Kaplan–Meier plot for survival according to Paris I criteria. Kap...Figure 7.4 Relationship between age at diagnosis and the probability of UDCA...Figure 7.5 Flowchart showing the guideline‐supported, response‐guided approa...Figure 7.6 Practical approach to drug management of most relevant symptoms i...

8 Chapter 8Figure 8.1 (a) Endoscopic retrograde cholangiography (ERC) in a patient with...Figure 8.2 Liver histology in PSC showing a portal field with bile duct chan...Figure 8.3 Dense portal tract inflammatory infiltrate comprising lymphocyte ...

9 Chapter 9Figure 9.1 IgG4‐related AIP histology at low power (left) showing an IgG imm...Figure 9.2 Imaging changes typical in IgG4‐related hepatobiliary disease sho...

10 Chapter 10Figure 10.1 Proposed algorithm to diagnose autoimmune liver diseases in pati...

11 Chapter 12Figure 12.1 (a) The diagnosis of osteoporosis is based on densitometric crit...Figure 12.2 (a) Pathogenesis of osteoporosis in primary biliary cholangitis....Figure 12.3 Diagnosis and management of osteoporosis in primary biliary chol...Figure 12.4 Percentage changes in lumbar bone mineral density (BMD) with res...

12 Chapter 13Figure 13.1 Strategies to reduce the risk of autoimmune liver disease recurr...

13 Chapter 15Figure 15.1 Overlap syndromes of the classical autoimmune liver diseases. PB...Figure 15.2 Distribution and degree of interface hepatitis across the spectr...Figure 15.3 Histologic features of PBC/AIH overlap syndrome in a 38‐year‐old...

14 Chapter 16Figure 16.1 Phenotypic features of (a) PSC‐related ulcerative colitis compar...

Autoimmune Liver Disease

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