Читать книгу Autoimmune Liver Disease - Группа авторов - Страница 42

 Autoimmunity results from the complex interplay of genetic, epigenetic, immunologic, and environmental factors.

 Environmental triggers initiate loss of tolerance to autoantigens in genetically susceptible individuals.

 Susceptible individuals must have inflammatory innate immune responses, human leukocyte antigen (HLA) alleles capable of autoantigen presentation to autoreactive T‐cell receptors, and autoreactive B cells to develop a specific autoimmune disease.

 Subsequently, additional immunologic mechanisms perpetuate chronic progressive inflammatory disease.

 Novel therapies based on immunopathogenic mechanisms in autoimmunity are in development.