Читать книгу DNA- and RNA-Based Computing Systems - Группа авторов - Страница 49

The integration of advances in nucleic acid nanotechnology and in nucleic acid aptamer technologies makes it possible to build novel nanoparticles playing intermediate roles between electronic computers and biological systems. Programming with biological molecules, especially with nucleic acids (NA), is now becoming very attractive due to their potential of functions ranging from simple fluorescence emission to sophisticated gene regulation in vivo. The structural behavior encompassed within their sequences can be predicted and manipulated using 2D folding algorithms. The resulting nucleic acid biopolymers can then be used as logic‐gated nano‐agents for specific biomedical applications. Fluorogenic RNA aptamers can be designed to function as a simple circuit within individual binary logic gates. This demonstrates the great potential of nucleic acid nanotechnology and holds promise to develop cutting‐edge technologies, especially if synergistically combined with other computing and nanorobotic systems.