Читать книгу Nanopharmaceutical Advanced Delivery Systems - Группа авторов - Страница 13

Vikas Jain*, Hitesh Kumar, Pallavi Chand, Sourabh Jain and Preethi S

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, India

Abstract

Various nanotechnology platforms have received notable attention in the field of medical biology, including diagnostics and therapy. In addition, research and development of engineered multifunctional nanoparticles as drug carriers has stimulated exponential development of applications in medicine. Lipid nanocarriers have been a very promising tool for the delivery of various drugs/therapeutic agents associated with solubility-, bioavailability-, and stability-related issues. Lipid nanocarriers including liposomes, solid lipid-based systems, self-emulsifying drug delivery system, nanoemulsions, nanostructured lipid carriers, cubosomes and hexosomes, etc. are being very promising lipidic carriers to deliver several drugs, therapeutics nucleic acids, antibodies, proteins/peptides, or ligand targeted agents. Lipids-based nanocarriers have the benefit of having exciting physicochemical behaviors such as higher bioavailability, least toxicity, higher drug loading, greater drug solubility, improved targeting effect of drug, etc. compared to others nanocarriers. This chapter includes the challenges and hurdles in lipid nano-formulations and their application in drug delivery in various diseases. The chapter provides a brief description of advantage, types of lipid nanocarriers, their preparation method, characteristic properties, and characterization/evaluation methods including instrumentations and application in the nanopharmaceutical field.

Keywords: Crystalline mesophases, drug delivery system, liposome, lipid nanocarriers, nanostructured lipid carriers, nanoemulsions, self-emulsifying drug delivery system, solid lipid nanoparticles