Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 443

About a decade ago, Douglas Kondziolka (now moved to New York University from Pittsburgh), led a promising trial of a different old lineage stem cell in older stroke patients. Because the current stem cells are more a modified and sophisticated type, researchers had to start over again with animal and safety tests. Researchers at University of Pittsburgh Medical Center (UPMC) and Stanford University are objectively working on recovery data after infusion of millions of stem cells directly into patients’ brains. The cells were extracted from adult bone marrow and given a booster containing a gene known as Notch, which is involved in the development of infant brains. The procedure ensues by making a burr hole through the skull and inserting a metal tube into the brain near the area of the stroke damage. The stem cells are then infused into the brain through the tube. Outcome is yet to be announced. No major side effects have been reported to date. Furthermore, the Stanford University–led team plans to use cells generated from human embryonic stem cells to improve recovery in the weeks and months following a stroke.