Читать книгу Successful Drug Discovery, Volume 5 - Группа авторов - Страница 3

1 Chapter 2Table 2.1 Selected examples of different target types that have been successf...

2 Chapter 4Table 4.1 Summary of the first results of randomized controlled trials testin...

3 Chapter 5Table 5.1 Ongoing CAR T cell clinical trials.

4 Chapter 6Table 6.1 Summary of CGRP/CGRP‐R mABs.

5 Chapter 7Table 7.1 Annualized bleeding rates for bleeding events treated with coagulat...

6 Chapter 8Table 8.1 R₁ Initial SAR based on the enzymatic activity of derivatives of 2,Table 8.2 R₂ Initial SAR based on the enzymatic activity of derivatives of N‐...Table 8.3 R₃ initial SAR based on the enzymatic activity of the phenyl‐glycin...Table 8.4 R₄ Initial SAR based on the enzymatic activity of derivatives of 2,Table 8.5 Cell potency of selected potentN‐phenyl glycine analogues.Table 8.6 Second round SAR optimization: enzymatic activity, cellular potency...Table 8.7 Reduction of hPXR activation leading to AG‐120.Table 8.8 Biochemical and Cellular Profiling ofAG‐120.Table 8.9In vitro ADME and in vivo PK properties of AG‐120.