Читать книгу Clinical Pancreatology for Practising Gastroenterologists and Surgeons - Группа авторов - Страница 133

Application of local anesthetics such as procaine in patients with AP is mainly used in the German‐speaking world. Local anesthetics have a membrane‐stabilizing effect and reversibly prevent the genesis and transmission of nervous stimuli. Furthermore, they exert potent anti‐inflammatory effects on virtually every level of the inflammatory cascade, prevent overactive immune responses without impairing host defense mechanisms, and modulate gastrointestinal motor functions. In addition, they display potent neuroprotective effects and inhibit phospholipase A2. Treatment with intravenous procaine (2 g per 24 hours) improved pain severity and reduced the demand for additional pain medication compared with placebo in a randomized double‐blind study published in 2011 [18]. However, no clinical trial has been published about the effects of procaine on pancreatic pain since then. The adverse effects of procaine are weakness, dizziness, hypertension, and skin rash in patients who are sensitive to the drug.