Читать книгу Clinical Pancreatology for Practising Gastroenterologists and Surgeons - Группа авторов - Страница 62

Severe AP is defined by persistent organ failure (>48 hours). Primary organ failure develops in the early phase of AP when cytokine cascades result in the systemic inflammatory response syndrome (SIRS). Secondary organ failure may develop later in the disease course (more than two weeks) as a result of infected pancreatic necrosis. Approximately 5–15% of AP patients develop a severe disease course, though this proportion may be as high as 40% in tertiary care referral centers [24,25]. Severe AP is associated with high morbidity and mortality (40–50%).