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Increased age and comorbid conditions do not mediate increased pancreatitis severity, but rather reduce a patient’s reserve to survive an extreme physiological stress [19]. Patients older than 75 years of age are at significantly increased risk of mortality at one and three months when compared with patients 35 years of age and younger. Similarly, a high Charlson Comorbidity Index is associated with increased mortality. While comorbidity burden is not typically included in a scoring system, age is part of most scoring systems (see Table 4.1).