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Microneedling is not only used for rejuvenation of the skin. Its use in dermatology and aesthetic medicine has expanded to include the treatment of acne scars, alopecia, dyspigmentation, alopecia, striae, and for many other indications. It can be utilized alone or in combination with other treatment modalities, such as chemical peels, platelet‐rich plasma, radiofrequency, subcision, punch elevation, and lasers. It is often used in conjunction with a topical formulation to enhance its penetration and action.

Microneedling is safely used for enhanced drug delivery to the deeper epidermis and dermis by bypassing the stratum corneum. This strategy has been utilized for burn patients and for rejuvenation, allowing cosmeceuticals to be delivered more deeply. Caution is necessary in deciding which topicals to use during delivery, as inflammation may occur and granulomas have been noted.