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Several breeds and their crosses may possess this variant that affects tolerance for ivermectin and many other drugs. If a dog inherits two copies of the MDR1 gene, one from each parent, we must be very careful with certain medications and usually choose not to use them at all. Dogs with one copy of the gene can usually tolerate low doses of drugs if they really need to be used. We recommend all dogs from susceptible breeds be tested so we can properly prescribe medications for them.

Exercise‐induced collapse (EIC) is just like it sounds – affected dogs collapse when exercising strenuously, especially in hot weather. This problem is seen especially in Labrador and golden retrievers but in other breeds as well. The problem is not common so we generally only test for it if a dog has symptoms or will be used for breeding.