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Accessing an implanted CVC requires puncturing the skin overlying the device; therefore, if line access is not required emergently, practitioners may wish to numb the skin over the port with a topical, lidocaine‐containing anesthetic. Care must be taken to access the port with a noncoring (Huber©) needle, as standard hypodermic needles will damage the septum of the port and prevent it from resealing properly when the line is de‐accessed. While the closed system of the implanted port boasts a decreased infection rate than that of externalized CVCs with routine use, it is critical to maintain proper aseptic technique when accessing these lines in the ED to avoid introducing infection at the access site. The skin overlying the implanted device should be cleansed with povidone‐iodine or chlorhexidine (for patients older than two months) prior to attempting access. Table 5.2 details the steps necessary to access an implanted port. As noted above in the section on accessing externalized CVCs, all equipment should be prepared prior to attempting port access, and any blood samples drawn from a port should be labeled carefully to indicate their origin.