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The term “gliomatosis cerebri” has been applied to exceptionally invasive diffusely infiltrating gliomas with involvement of at least three cerebral lobes, frequent bilateral growth and infratentorial extension [3, 11]. These tumors mostly display an astrocytic phenotype, while oligodendroglial and mixed morphology can also present with such extensive growth patterns. Gliomatosis cerebri is a genetically heterogeneous group of lesions carrying either wild-type or mutant IDH1/IDH2. Their biological behavior usually corresponds to WHO grade III [3]. Nevertheless, this pathological designation was abandoned in the updated WHO classification of CNS tumors (2016) [11] as a distinct entity and currently is considered a growth pattern found in many gliomas. Further studies are necessary to clarify the biological basis for the unusually widespread neoplastic infiltration in such cases [11].