Читать книгу Acute Kidney Injury - Basic Research and Clinical Practice - Группа авторов - Страница 42

Interleukin 18 (IL-18) is a pro-inflammatory cytokine. Similar to NGAL, it is produced in the renal tubule cells and is detectable in urine. As observed with NGAL, several studies have demonstrated that levels of urinary IL-18 are raised at 4–6 h post CPB, significantly earlier than SCr and that IL-18 may have potential in the prediction of severity of AKI [35, 36]. However, despite early promise, several meta-analyses have derived AUCs ranging from 0.66 to 0.77 [38, 39]. In keeping with NGAL, raised levels are also known to correlate with other co-morbidities including cardiac and lung injury, and urinary tract infection [40]. This is unsurprising, given that IL-18 is a non-specific marker of infection and as such may be elevated for reasons other than AKI.