Читать книгу Acute Kidney Injury - Basic Research and Clinical Practice - Группа авторов - Страница 45

IGFBP-7 and TIMP-2 are proteins that are implicated in G1 cell cycle arrest as a response to renal insult and unlike other candidate molecules do not exhibit non-specific elevations [45, 46]. In postoperative patients a pre-planned post hoc analysis from both trials including cardiothoracic and emergency surgery demonstrated an AUROC of 0.84 in terms of predicting severe AKI within a 12-h window. Subsequent studies in cardiothoracic patients demonstrated interesting kinetics of these biomarkers of renal stress. Levels of TIMP-2/IGFBP-7 were significantly increased on the first postoperative day (AUROC 0.7), but on the day of surgery, the values were significantly lower [47].

A subsequent study on 107 major general surgical, non-cardiac patients (i.e. trauma, hepatobiliary and vascular) performed postoperatively on the day of surgery delivered an AUROC of 0.85 with high TIMP-2/IGFBP-7 levels being associated with an increased risk of requiring renal replacement therapy and overall mortality [48].