Читать книгу Metabolic Syndrome Consequent to Endocrine Disorders - Группа авторов - Страница 18

GH exerts anabolic actions on muscle and bone with marked lipolytic effect in fat tissue. The impaired body composition in GHD results in a prevalent central fat distribution due to visceral fat accumulation contributing to an increased cardiometabolic risk. Approximately 7% higher fat mass was demonstrated in GHD patients compared with age-, sex-, and height-adjusted predicted values [50]. It has been shown that adult GHD patients with the same BMI (of 23) had higher waist circumference and visceral fat compared to controls [51].

Long-term GHRT effectively improves body composition in GHD patients. GHRT produces a gradual increase in lean body mass by 2–5 kg and reduction in fat mass by approximately 4–6 kg of visceral fat [52]. The gain in lean body mass is maintained for at least 10 years of GHRT in both men and women [52]. Improvement in body composition reflects reduction in insulin resistance with beneficial effect on vascular risk profile in these patients [52].