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Conclusions

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Over the last 40 years, CRRT has been widely utilized for the management of AKI in critically ill patients and it has greatly benefited from important technological advances in machine design and the application of novel, more complex modalities that have greatly expanded the field of extracorporeal therapies in the intensive care unit. Concurrently, the treatment of the AKI patient has evolved from the single replacement of kidney function to the support of the patient as a whole (multiple organ support therapy), incorporating technologies that assist in the management of multiple organ dysfunctions. Necessarily, such integrated care must be supported by information technologies, which assist in data collection and integration, delivery of personalized prescriptions, and measurement of results. Such technologies will allow the prescription and delivery of precision CRRT, and will contribute to the improvement of patient care.

A significant number of advances have taken place since the beginning of CRRT. Progress has been made in technology as well as in the understanding of AKI. New biomaterials and new devices are now available and new frontiers are on the horizon. The evolution of technology in critical care nephrology and CRRT has been enormous and further evolution is expected in the future. The final target is the improvement of patient care and amelioration of clinical outcomes [4045].

40 Years of Continuous Renal Replacement Therapy

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