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Conclusions

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In this report, we reviewed the new pathway by which albumin travels through caveolae in both glomerular endothelial and epithelial cells. This caveolae-dependent pathway appears to match several aspects of pathophysiology in glomerulonephritis, including the narrowing of fenestra in glomerular endothelial cells and the fusion of foot processes in podocytes. We suspect that this new theory may become part of the general etiology of albuminuria along with the fenestral pathway and the slit membrane pathway.

Recent Advances in the Pathogenesis and Treatment of Kidney Diseases

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