Читать книгу Recent Research in Nutrition and Growth - Группа авторов - Страница 37

Longitudinal studies of human cohorts, experimental animal models, and farm animal species have consistently observed that suboptimal nutrition during early life has long-term consequences on the skeletal musculature [1–3]. This outcome appears to be critically dependent on the developmental age when the insult is experienced. Thus, understanding the specific cellular events responsible for muscle growth and development is essential in order to identify the windows of development when the organism is especially at risk for the reprogramming of skeletal muscle mass.

Fig. 1. Summary of major events that occur during myogenesis and muscle hypertrophy, and the corresponding developmental stages and chronological ages during which they occur in the human, rodents, and pigs [data compiled from references 5, 7, 10–15, 19–21, 23–24]. ED, embryonic day; PMA, postmenstrual age.