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Epithelial-Derived Tumours

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The majority of epithelium-derived tumours affecting different anatomic sites of the skull base region are malignant. In general, sinonasal carcinomas encompass different types and commonly affect the maxillary sinus (60%), nasal cavity (22%), ethmoid sinus (15%) and, less frequently, the frontal and sphenoid sinuses (3%). Carcinomas arise either de novo from squamous epithelium, squamous metaplasia of respiratory epithelium, or rarely preexisting squamous papillomas, especially the inverted form. The majority of these malignancies are squamous carcinomas and, less commonly, adenocarcinomas and neuroendocrine carcinomas.

Anterior Skull Base Tumors

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