Читать книгу Assisted Reproduction Techniques - Группа авторов - Страница 96

The most common cancers in men during their reproductive years are leukemia, Hodgkin lymphomas and testicular germ cell tumors [21]. Semen analysis may be abnormal in men with germ cell tumors. Furthermore, there is evidence that the integrity of sperm DNA is affected even before initiation of cancer therapy in men with Hodgkin lymphomas and testicular cancers [13]. Chemotherapeutic agents, particularly alkylating agents such as cyclophosphamide, can have profound gonadotoxic effects. Radiotherapy, even at low doses, is toxic to sperm [13]. Thus, the man in Case History 3 should be offered the opportunity of sperm banking. Men with testicular cancer who cannot produce a sample or are azoospermic can undergo surgical sperm retrieval (see Chapter 91).