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Minor or rapidly improving symptoms

Seizure at onset of stroke

Major surgery within 14 days

Prior stroke or serious head trauma with past 3 months

Known history of intracranial hemorrhage

Sustained blood pressure >185/110 mmHg

Aggressive treatment necessary to lower blood pressure

Symptoms suggestive of subarachnoid hemorrhage

Gastrointestinal or genitourinary hemorrhage in last 21 days

Arterial puncture at a noncompressible site within 7 days

Heparin administration within 48 h with elevated aPTT

Prothrombin time >15 s

Platelet count <100,000 μL

Serum glucose <50 mg/dL or >400 mg/dL