Читать книгу Computation in BioInformatics - Группа авторов - Страница 40

The 3D structures of most proteins have not recently been resolved, and huge numbers of the proteins do not have a known ligand. In this circumstance, neither structure-based strategies nor ligand-based techniques can be utilized to lead identification and advancement. Along these lines, a technique to foresee ligand-protein interactions (LPIs) without 3D or ligand data is earnestly required. As of late, a succession-based medication configuration model for LPI was developed exclusively based on the essential grouping of proteins and the basic highlights of little particles utilizing the help support vector machine (SVM) approach. This model was prepared utilizing 15,000 LPIs between 626 proteins and more than 10,000 dynamic mixes gathered from the Binding Database. In the approval trial of this model, nine novel dynamic mixes against four pharmacologically significant targets were discovered utilizing just the arrangement of the objective. This is the principal case of a fruitful arrangement-based medication configuration crusade.